Department of Ophthalmology, the Second Hospital of Hebei Medical University, Shijiazhuang, China.
Department of Ophthalmology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China.
Retina. 2021 Sep 1;41(9):1921-1929. doi: 10.1097/IAE.0000000000003130.
To evaluate the sensitivity and specificity of multispectral imaging (MSI), a noninvasive imaging technique composed of a series of monochromatic scanning light, for polypoidal choroidal vasculopathy (PCV).
This was a prospective observational study. Polypoidal lesions on MSI are defined by oval or lobular hyperreflective oval lesion with dark hyporeflective center. Branching vascular networks on MSI is featured by hyperreflective interlacing signal. Detection sensitivity and specificity of polypoidal lesions was compared with indocyanine green angiography, whereas sensitivity and specificity of branching vascular networks, subretinal fluid, and pigment epithelium detachment were compared with optical coherence tomography.
Among 67 eyes, 38 eyes (56.7%) were diagnosed with PCV, 7 eyes (10.4%) with neovascular age-related macular degeneration, 13 eyes (19.4%) with central serous chorioretinopathy, 6 eyes (9.0%) with pathological myopia, and 3 eyes (4.5%) with idiopathic choroidal neovascularization. Compared with indocyanine green angiography, the sensitivity and specificity for diagnosing PCV by MSI alone was 84.21% and 93.10%, respectively, and the positive predictive value and the negative predictive value for PCV by MSI was 94.12% and 81.82%, respectively. The sensitivity and specificity for detecting polypoidal lesions were 84.21% and 93.10% compared with indocyanine green angiography. Compared with optical coherence tomography, the sensitivity and specificity for detecting branching vascular networks were 95.83% and 88.37%, for the subretinal fluid were 76.92% and 86.67%, and for the pigment epithelium detachment were 91.11% and 90.91%, respectively.
Multispectral imaging allowed noninvasive visualization of polypoidal lesions and branching vascular networks and may serve as a new diagnostic option for PCV.
评估多光谱成像（MSI）作为一种由一系列单色扫描光组成的无创成像技术，对息肉样脉络膜血管病变（PCV）的敏感性和特异性。
这是一项前瞻性观察性研究。MSI 上的息肉样病变定义为具有暗低反射中心的椭圆形或叶状高反射性椭圆形病变。MSI 上的分支血管网络的特征是高反射性交织信号。与吲哚青绿血管造影相比，比较了息肉样病变的检测敏感性和特异性，而分支血管网络、视网膜下液和色素上皮脱离的敏感性和特异性与光学相干断层扫描相比。
在 67 只眼中，38 只眼（56.7%）诊断为 PCV，7 只眼（10.4%）为新生血管性年龄相关性黄斑变性，13 只眼（19.4%）为中心性浆液性脉络膜视网膜病变，6 只眼（9.0%）为病理性近视，3 只眼（4.5%）为特发性脉络膜新生血管。与吲哚青绿血管造影相比，MSI 单独诊断 PCV 的敏感性和特异性分别为 84.21%和 93.10%，MSI 诊断 PCV 的阳性预测值和阴性预测值分别为 94.12%和 81.82%。与吲哚青绿血管造影相比，检测息肉样病变的敏感性和特异性分别为 84.21%和 93.10%。与光学相干断层扫描相比，分支血管网络的敏感性和特异性分别为 95.83%和 88.37%，视网膜下液为 76.92%和 86.67%，色素上皮脱离为 91.11%和 90.91%。
多光谱成像允许非侵入性地可视化息肉样病变和分支血管网络，可能成为 PCV 的一种新的诊断选择。
