Wang Min, Zhou Yao, Gao Simon S, Liu Wei, Huang Yongheng, Huang David, Jia Yali
Department of Ophthalmology and Vision Science Eye and ENT Hospital, Fudan University, Shanghai, People's Republic of China 2Key Laboratory of Visual Impairment and Restoration of Shanghai, Shanghai, People's Republic of China.
Department of Ophthalmology and Vision Science Eye and ENT Hospital, Fudan University, Shanghai, People's Republic of China.
Invest Ophthalmol Vis Sci. 2016 Jul 1;57(9):OCT526-32. doi: 10.1167/iovs.15-18955.
We observed and analyzed the morphologic characteristics of polypoidal lesions and abnormal branching vascular network (BVN) in patients with polypoidal choroidal vasculopathy (PCV) by optical coherence tomography angiography (OCTA).
A retrospective observational case series was done of patients with PCV. All patients were scanned with a 70-kHz spectral-domain OCT system using the split-spectrum amplitude-decorrelation angiography (SSADA) algorithm to distinguish blood flow from static tissue. The OCTA images of these patients were compared to those from indocyanine green angiography (ICGA). Semiautomated segmentation was used to further analyze the polypoidal lesion and the BVN.
We studied 13 eyes of 13 patients 51 to 69 years old. A total of 11 patients were treatment-naive. Two patients had multiple anti-VEGF injections and one underwent photodynamic therapy (PDT). Optical coherence tomography angiography was able to detect the BVN in all cases. Using cross-sectional OCTA, BVN locations were shown to be in the space between the RPE and Bruch's membrane. Using en face OCTA, the BVN vascular pattern could be shown more clearly than by ICGA. Polypoidal lesions showed high flow signals in different patterns in 12 cases in the outer retina slab. Using cross-sectional OCTA, the polyps were shown to be just below the top of the pigment epithelial detachment (PED). In one case, the polypoidal lesion was not detectable at the outer retina slab.
Optical coherence tomography angiography is a noninvasive imaging tool for detecting vascular changes in PCV. Branching vascular networks showed more clearly on OCTA than on ICGA. Polypoidal lesions had variable patterns on OCTA and were not always detected. The OCTA patterns of the polypoidal lesions and the BVN are helpful in understanding the pathology of PCV.
我们通过光学相干断层扫描血管造影（OCTA）观察并分析了息肉样脉络膜血管病变（PCV）患者的息肉样病变和异常分支血管网（BVN）的形态特征。
对PCV患者进行了一项回顾性观察病例系列研究。所有患者均使用70kHz谱域OCT系统，采用分裂频谱幅度去相关血管造影（SSADA）算法进行扫描，以区分血流与静态组织。将这些患者的OCTA图像与吲哚菁绿血管造影（ICGA）图像进行比较。采用半自动分割进一步分析息肉样病变和BVN。
我们研究了13例年龄在51至69岁之间患者的13只眼。共有11例患者未接受过治疗。2例患者接受过多次抗VEGF注射，1例接受过光动力疗法（PDT）。光学相干断层扫描血管造影在所有病例中均能检测到BVN。使用横断面OCTA，BVN位于视网膜色素上皮（RPE）和布鲁赫膜之间的间隙。使用表面OCTA，BVN的血管形态比ICGA显示得更清晰。12例患者的息肉样病变在外视网膜层呈现出不同模式的高血流信号。使用横断面OCTA，息肉显示位于色素上皮脱离（PED）顶部下方。1例患者在外视网膜层未检测到息肉样病变。
光学相干断层扫描血管造影是一种用于检测PCV血管变化的非侵入性成像工具。OCTA上显示的分支血管网比ICGA更清晰。息肉样病变在OCTA上具有可变模式，且并非总能被检测到。息肉样病变和BVN的OCTA模式有助于理解PCV的病理。
