Hvarfner A, Larsson R, Mörlin C, Rastad J, Wide L, Akerström G, Ljunghall S
Department of Internal Medicine, University Hospital, Uppsala, Sweden.
J Hypertens. 1988 Jan;6(1):71-7.
Relationships between cytosolic free calcium ([Ca2+]i) in platelets, indices of systemic calcium metabolism and blood pressure were examined in 86 subjects; 29 patients with untreated and 29 patients with treated essential hypertension, six patients with borderline hypertension and 22 healthy reference subjects. In order to analyse interactions between the variables, multivariate statistical analyses were employed. The patients with untreated hypertension had higher [Ca2+]i values in non-activated platelets (P = 0.04) and lower levels of plasma ionized calcium (P = 0.02) than the reference subjects. In multivariate models analysing platelet [Ca2+]i mean blood pressure (MBP), plasma ionized calcium, serum parathyroid hormone (PTH) and body mass index (BMI), the relationship between platelet [Ca2+]i and blood pressure was attenuated (P = 0.13), whereas the inverse relationships between plasma ionized calcium and MBP (P = 0.01) and between platelet [Ca2+]i and serum PTH (P = 0.06) seen in univariate analyses persisted. According to the multivariate models the [Ca2+]i value explained only 5% of the MBP variability. Thus, the data from this investigation do not support a close relationship between basal platelet [Ca2+]i and blood pressure. The inverse relationship between plasma ionized calcium and blood pressure, independent of platelet [Ca2+]i and serum PTH, suggests a direct interaction between plasma ionized calcium and blood pressure regulation.
对86名受试者的血小板胞浆游离钙（[Ca2+]i）、全身钙代谢指标与血压之间的关系进行了研究；其中包括29例未经治疗的原发性高血压患者、29例已治疗的原发性高血压患者、6例临界高血压患者以及22名健康对照者。为了分析各变量之间的相互作用，采用了多变量统计分析方法。未经治疗的高血压患者与对照者相比，其未激活血小板中的[Ca2+]i值更高（P = 0.04），血浆离子钙水平更低（P = 0.02）。在分析血小板[Ca2+]i、平均血压（MBP）、血浆离子钙、血清甲状旁腺激素（PTH）和体重指数（BMI）的多变量模型中，血小板[Ca2+]i与血压之间的关系减弱（P = 0.13），而单变量分析中所见的血浆离子钙与MBP之间的负相关关系（P = 0.01）以及血小板[Ca2+]i与血清PTH之间的负相关关系（P = 0.06）仍然存在。根据多变量模型，[Ca2+]i值仅解释了MBP变异性的5%。因此，本研究的数据不支持基础血小板[Ca2+]i与血压之间存在密切关系。血浆离子钙与血压之间的负相关关系独立于血小板[Ca2+]i和血清PTH，提示血浆离子钙与血压调节之间存在直接相互作用。
