Hvarfner A, Bergström R, Mörlin C, Wide L, Ljunghall S
Department of Internal Medicine, University Hospital, Uppsala, Sweden.
J Hypertens. 1987 Aug;5(4):451-6.
Relations between indices of mineral metabolism and blood pressure were examined in 182 subjects, comprising 58 patients with essential hypertension (EHT) and 124 healthy subjects attending a general health survey. Multivariate techniques of statistical analysis were employed to test the hypothesis of different relationships between blood pressure and calcium metabolism within the subpopulations and to eliminate confounding effects of age, sex and obesity. Plasma ionized calcium was inversely related and the urinary calcium excretion positively related to blood pressure in the total group. This was not significantly different between the groups. Serum parathyroid hormone (PTH) was, however, related to diastolic blood pressure only in the EHT group. The EHT patients had significantly lower plasma levels of ionized calcium, significantly higher levels of PTH and significantly greater excretion of calcium in the urine than the healthy subjects. The results of this investigation support the hypothesis that among patients with EHT the renal tubular reabsorption of calcium is impaired resulting in a reduction of plasma ionized calcium and thereby stimulation of PTH. The findings of linear relationships suggests the possibility of a direct association between calcium metabolism and the regulation of blood pressure.
对182名受试者的矿物质代谢指标与血压之间的关系进行了研究，其中包括58例原发性高血压（EHT）患者和124名参加一般健康调查的健康受试者。采用多变量统计分析技术来检验亚组内血压与钙代谢之间不同关系的假设，并消除年龄、性别和肥胖的混杂影响。在总人群中，血浆离子钙呈负相关，尿钙排泄与血压呈正相关。两组之间无显著差异。然而，血清甲状旁腺激素（PTH）仅在EHT组中与舒张压相关。与健康受试者相比，EHT患者的血浆离子钙水平显著降低，PTH水平显著升高，尿钙排泄显著增加。这项研究的结果支持以下假设：在EHT患者中，肾小管对钙的重吸收受损，导致血浆离子钙减少，从而刺激PTH。线性关系的发现表明钙代谢与血压调节之间可能存在直接关联。
