Foulkes R, Gardiner S M, Bennett T
Department of Physiology and Pharmacology, Medical School, Queen's Medical Centre, Nottingham, UK.
J Hypertens. 1988 Feb;6(2):117-22.
Blood pressure was measured indirectly (using the tail-cuff method) and intra-arterially in conscious rats following one of three experimental procedures carried out in order to determine which resulted in the most marked and reproducible form of adrenal regeneration hypertension (ARH). All rats were unilaterally adrenalectomized and given NaCl solution (1%). In some rats, the remaining adrenal gland was either enucleated (AE rats) or compressed (AC rats) but both kidneys were left intact. During the fourth week after surgery, indirectly measured systolic blood pressure was higher in AE and AC rats than in sham-operated (SO) rats but, when measured intra-arterially, the magnitude of the developed hypertension was small (AC rats) or was absent altogether (AE rats). However, when a kidney was removed at the time of enucleation (AEN rats), the levels of systolic blood pressure, measured indirectly or intra-arterially, were markedly and consistently higher than in the corresponding group of uninephrectomized SO rats. The magnitude of the developed hypertension was similar in mature male and immature female AEN rats. We conclude that mature male rats, unilaterally nephro-adrenalectomized and given NaCl solution (1%), provide a marked and reproducible model of ARH.
为了确定哪种实验程序会导致最显著且可重复的肾上腺再生性高血压（ARH）形式，在清醒大鼠中采用了三种实验程序之一，之后通过间接测量（采用尾套法）和动脉内测量来测定血压。所有大鼠均进行单侧肾上腺切除术，并给予1%的氯化钠溶液。在一些大鼠中，对剩余的肾上腺进行摘除（AE大鼠）或压迫（AC大鼠），但双侧肾脏均保持完整。在术后第四周，间接测量的收缩压在AE和AC大鼠中高于假手术（SO）大鼠，但动脉内测量时，所产生的高血压程度较小（AC大鼠）或完全不存在（AE大鼠）。然而，当在摘除肾上腺时同时切除一个肾脏（AEN大鼠），间接或动脉内测量的收缩压水平均显著且持续高于相应的单侧肾切除SO大鼠组。成熟雄性和未成熟雌性AEN大鼠所产生的高血压程度相似。我们得出结论，单侧肾-肾上腺切除并给予1%氯化钠溶液的成熟雄性大鼠可提供一种显著且可重复的ARH模型。
