Eisenstein B, Bengele H H, Alexander E A
Am J Physiol. 1980 Mar;238(3):E220-2. doi: 10.1152/ajpendo.1980.238.3.E220.
To better define the relationship between adrenal enucleation (AE), sodium retention and adrenal regeneration hypertension (ARH), we measured daily sodium balance in rats after bilateral adrenal enucleation with (AEN) and without uninephrectomy (AE), and before and after development of ARH, along with the appropriate control groups. We found that both AE and AEN groups retained sodium during 7 days after surgery; AE 1.16 +/- 0.24 and AEN 1.32 +/- 0.33 meq/100 g body wt. Sham-operated, uninephrectomized rats and AE rats treated with spironolactone were in zero sodium balance. In the AEN rats after the development of ARH (BP greater than 150 Torr), zero sodium balance was also noted. Only AEN rats developed hypertension while sham-operated, uninephrectomized rats and AE rats with both kidneys remained normotensive for 28 wk. In summary, we have demonstrated that for 1 wk after AE, rats are in positive sodium balance and this is reversed by spironolactone but not by uninephrectomy.
为了更好地明确肾上腺剜除术（AE）、钠潴留与肾上腺再生性高血压（ARH）之间的关系，我们对双侧肾上腺剜除术（有单侧肾切除术的AEN和无单侧肾切除术的AE）后以及ARH发生前后的大鼠每日钠平衡进行了测量，并设置了相应的对照组。我们发现，AE组和AEN组在术后7天内均出现钠潴留；AE组为1.16±0.24，AEN组为1.32±0.33 毫当量/100克体重。假手术、单侧肾切除的大鼠以及接受螺内酯治疗的AE大鼠钠平衡为零。在AEN大鼠发生ARH（血压大于150托）后，也观察到钠平衡为零。只有AEN大鼠出现高血压，而假手术、单侧肾切除的大鼠以及保留双肾的AE大鼠在28周内血压保持正常。总之，我们已经证明，AE术后1周内大鼠处于钠正平衡状态，螺内酯可逆转这种状态，而单侧肾切除术则不能。
