Lemke P M, Gautieri R F
Res Commun Chem Pathol Pharmacol. 1987 Mar;55(3):367-74.
The investigation was undertaken in an attempt to provide a more simple animal model for studying renal hypertension in the rat. Rats were surgically altered by two procedures, single nephrectomy and single nephrectomy plus encapsulation, the latter completed in a common operation. Systolic blood pressure was observed at various intervals of 14, 30, and 60 days. Systolic blood pressure was also observed at an 80 day interval in a control group. The results are as follows: Untreated Control - Systolic blood pressure was not significantly altered over an 80 day interval; Single Nephrectomy - Systolic blood pressure was not significantly altered at the 14, 30, or 60 day intervals (one animal died in this group immediately after surgery); Single Nephrectomy and Encapsulation - Of the 18 animals in this group 5 had significantly elevated systolic blood pressure by the 14 day interval, 1 became hypertensive by the 60 day interval, 6 showed no significant effect on systolic blood pressure, and 6 animals succumbed. Necropsies on the 6 animals which had no effect showed that the encapsulation procedure had failed.
开展此项研究旨在为大鼠肾性高血压的研究提供一种更为简易的动物模型。通过两种手术方式对大鼠进行处理，即单侧肾切除术以及单侧肾切除术加包囊术，后者通过常规手术完成。在术后14天、30天和60天的不同时间间隔测量收缩压。在对照组中，也于术后80天测量收缩压。结果如下：未处理的对照组——在80天的时间间隔内收缩压无显著变化；单侧肾切除术组——在术后14天、30天或60天收缩压无显著变化（该组中有1只动物在术后立即死亡）；单侧肾切除术加包囊术组——该组的18只动物中，有5只在术后14天收缩压显著升高，1只在术后60天出现高血压，6只收缩压无显著变化，还有6只动物死亡。对6只收缩压无变化的动物进行尸检发现包囊术失败。
