Kos Kevin, de Visser Karin E
Division of Tumor Biology & Immunology, Oncode Institute, Netherlands Cancer Institute, Amsterdam, the Netherlands.
Division of Tumor Biology & Immunology, Oncode Institute, Netherlands Cancer Institute, Amsterdam, the Netherlands; Department of Immunology, Leiden University Medical Center, Leiden, the Netherlands.
Cancer Cell. 2021 Mar 8;39(3):301-303. doi: 10.1016/j.ccell.2021.01.009. Epub 2021 Jan 28.
Neutrophils can facilitate the metastatic spread of cancer; however, how neutrophils are activated at metastatic sites remains poorly understood. In this issue, Xiao et al. demonstrate that the protease cathepsin C, secreted by breast cancer cells, triggers neutrophils to form neutrophil extracellular traps in the metastatic niche, thereby promoting lung metastasis.
中性粒细胞可促进癌症的转移扩散；然而，中性粒细胞在转移部位是如何被激活的仍知之甚少。在本期杂志中，肖等人证明，乳腺癌细胞分泌的蛋白酶组织蛋白酶C会触发中性粒细胞在转移微环境中形成中性粒细胞胞外陷阱，从而促进肺转移。
