中性粒细胞在肿瘤和细胞毒性免疫细胞之间形成一道坚不可摧的屏障。
Neutrophils Create an ImpeNETrable Shield between Tumor and Cytotoxic Immune Cells.
机构信息
Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT 84112, USA.
Department of Oncological Sciences, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT 84112, USA.
出版信息
Immunity. 2020 May 19;52(5):729-731. doi: 10.1016/j.immuni.2020.04.009.
Abstract
Neutrophil extracellular traps (NETs) can promote tumor growth and metastases, but whether NETs impact the tumor immune microenvironment remains underexplored. In this issue of Immunity, Teijeira et al. discover that NETs shield tumor cells from cytotoxic immune cells, resulting in impaired tumor clearance.
摘要
中性粒细胞胞外陷阱（NETs）可促进肿瘤生长和转移，但 NETs 是否影响肿瘤免疫微环境仍未得到充分探索。在本期《免疫》杂志中，Teijeira 等人发现，NETs 可使肿瘤细胞免受细胞毒性免疫细胞的攻击，导致肿瘤清除受损。
相似文献
1
Neutrophils Create an ImpeNETrable Shield between Tumor and Cytotoxic Immune Cells.中性粒细胞在肿瘤和细胞毒性免疫细胞之间形成一道坚不可摧的屏障。
Immunity. 2020 May 19;52(5):729-731. doi: 10.1016/j.immuni.2020.04.009.
2
NETosis: Sculpting tumor metastasis and immunotherapy.中性粒细胞胞外诱捕网：塑造肿瘤转移和免疫治疗。
Immunol Rev. 2024 Jan;321(1):263-279. doi: 10.1111/imr.13277. Epub 2023 Sep 15.
3
No NETs no TIME: Crosstalk between neutrophil extracellular traps and the tumor immune microenvironment.无 NETs 无 TIME：中性粒细胞胞外诱捕网与肿瘤免疫微环境的相互作用。
Front Immunol. 2022 Dec 23;13:1075260. doi: 10.3389/fimmu.2022.1075260. eCollection 2022.
4
Influence of Interleukin-8 and Neutrophil Extracellular Trap (NET) Formation in the Tumor Microenvironment: Is There a Pathogenic Role?肿瘤微环境中白细胞介素-8 和中性粒细胞胞外诱捕网（NET）形成的影响：是否存在致病作用？
J Immunol Res. 2019 Apr 10;2019:6252138. doi: 10.1155/2019/6252138. eCollection 2019.
5
The Emerging Role of Neutrophil Extracellular Traps (NETs) in Tumor Progression and Metastasis.中性粒细胞胞外诱捕网（NETs）在肿瘤进展和转移中的新兴作用。
Front Immunol. 2020 Sep 16;11:1749. doi: 10.3389/fimmu.2020.01749. eCollection 2020.
6
NETs unleashed: neutrophil extracellular traps boost chemotherapy against colorectal cancer.NETs 被释放：中性粒细胞胞外诱捕网增强结直肠癌的化疗效果。
J Clin Invest. 2024 Mar 1;134(5):e178344. doi: 10.1172/JCI178344.
7
Neutrophil extracellular traps in nasal secretions of patients with stable and exacerbated chronic rhinosinusitis and their contribution to induce chemokine secretion and strengthen the epithelial barrier.鼻腔分泌物中中性粒细胞胞外诱捕网在稳定期和加重期慢性鼻-鼻窦炎患者中的作用及其对趋化因子分泌的诱导作用和增强上皮屏障的作用。
Clin Exp Allergy. 2019 Oct;49(10):1306-1320. doi: 10.1111/cea.13448. Epub 2019 Jul 12.
8
Evidence and impact of neutrophil extracellular traps in malignant melanoma.中性粒细胞胞外诱捕网在恶性黑色素瘤中的证据和影响。
Pigment Cell Melanoma Res. 2020 Jan;33(1):63-73. doi: 10.1111/pcmr.12818. Epub 2019 Aug 29.
9
Immunoregulation and clinical significance of neutrophils/NETs-ANGPT2 in tumor microenvironment of gastric cancer.中性粒细胞/胞外诱捕网-ANGPT2 在胃癌肿瘤微环境中的免疫调节作用及临床意义。
Front Immunol. 2022 Sep 12;13:1010434. doi: 10.3389/fimmu.2022.1010434. eCollection 2022.
10
Neutrophil Extracellular Traps Induced by IL8 Promote Diffuse Large B-cell Lymphoma Progression via the TLR9 Signaling.白细胞介素 8 诱导的中性粒细胞胞外诱捕网促进弥漫性大 B 细胞淋巴瘤进展的机制研究
**解析**：原句中“Neutrophil Extracellular Traps”直译为“中性粒细胞胞外诱捕网”，但这种翻译可能会让读者感到困惑，因此在译文里，使用了缩写“NETs”来表示。
Clin Cancer Res. 2019 Mar 15;25(6):1867-1879. doi: 10.1158/1078-0432.CCR-18-1226. Epub 2018 Nov 16.
引用本文的文献
1
Neutrophils in Cancer: Phenotypic Heterogeneity Across Tumor Models and Significant Alteration of Splenic Neutrophil Phenotype in Lymphosarcoma RLS Model Following DNase I Treatment.癌症中的中性粒细胞：跨肿瘤模型的表型异质性以及在DNase I处理后的淋巴肉瘤RLS模型中脾中性粒细胞表型的显著改变。
Cancers (Basel). 2025 Aug 12;17(16):2631. doi: 10.3390/cancers17162631.
2
Dual Nature of Neutrophil Extracellular Traps (NETs)-From Cancer's Ally to Therapeutic Target.中性粒细胞胞外诱捕网（NETs）的双重性质——从癌症的盟友到治疗靶点
Cells. 2025 Aug 5;14(15):1200. doi: 10.3390/cells14151200.
3
The Role of Neutrophil Extracellular Traps (NETs) in the Pathogenesis of Ovarian Cancer: New Insight and Future Perspectives.中性粒细胞胞外诱捕网（NETs）在卵巢癌发病机制中的作用：新见解与未来展望
Mol Biotechnol. 2025 Jul 12. doi: 10.1007/s12033-025-01473-x.
4
Ovarian cancer, neutrophil hitchhiking, and NETs: unraveling their role in pathogenesis and management.卵巢癌、中性粒细胞搭便车与中性粒细胞胞外陷阱：揭示它们在发病机制及治疗中的作用
Med Oncol. 2025 Jun 30;42(8):302. doi: 10.1007/s12032-025-02860-9.
5
Tumor-associated neutrophils and neutrophil extracellular traps in lung cancer: antitumor/protumor insights and therapeutic implications.肺癌中的肿瘤相关中性粒细胞与中性粒细胞胞外诱捕网：抗肿瘤/促肿瘤见解及治疗意义
Med Oncol. 2025 Jun 16;42(7):266. doi: 10.1007/s12032-025-02831-0.
6
Exploring neutrophil extracellular traps: mechanisms of immune regulation and future therapeutic potential.探索中性粒细胞胞外诱捕网：免疫调节机制及未来治疗潜力
Exp Hematol Oncol. 2025 May 29;14(1):80. doi: 10.1186/s40164-025-00670-3.
7
Dipeptidase-1-knockout mice develop invasive tumors with features of microsatellite-unstable colorectal cancer.二肽酶-1基因敲除小鼠会发生具有微卫星不稳定型结直肠癌特征的侵袭性肿瘤。
JCI Insight. 2025 Apr 3;10(9). doi: 10.1172/jci.insight.186938. eCollection 2025 May 8.
8
[Dual Roles of Neutrophil Extracellular Traps in Lung Cancer:
Mechanism Exploration and Therapeutic Prospects].[中性粒细胞胞外陷阱在肺癌中的双重作用：机制探索与治疗前景]
Zhongguo Fei Ai Za Zhi. 2025 Jan 20;28(1):63-68. doi: 10.3779/j.issn.1009-3419.2025.101.01.
9
Prognosis and immune infiltration prediction in neuroblastoma based on neutrophil extracellular traps-related gene signature.基于中性粒细胞胞外诱捕网相关基因特征的神经母细胞瘤预后及免疫浸润预测
Sci Rep. 2025 Feb 13;15(1):5343. doi: 10.1038/s41598-025-88608-x.
10
A Neutrophil Extracellular Traps-Related Signature Predicts Clinical Outcomes and Identifies Immune Landscape in Ovarian Cancer.一种与中性粒细胞胞外诱捕网相关的特征可预测卵巢癌的临床结局并识别其免疫格局。
J Cell Mol Med. 2024 Dec;28(24):e70302. doi: 10.1111/jcmm.70302.
本文引用的文献
1
CXCR1 and CXCR2 Chemokine Receptor Agonists Produced by Tumors Induce Neutrophil Extracellular Traps that Interfere with Immune Cytotoxicity.肿瘤产生的 CXCR1 和 CXCR2 趋化因子受体激动剂诱导中性粒细胞细胞外陷阱，干扰免疫细胞毒性。
Immunity. 2020 May 19;52(5):856-871.e8. doi: 10.1016/j.immuni.2020.03.001. Epub 2020 Apr 13.
2
Neutrophil Extracellular Traps Drive Mitochondrial Homeostasis in Tumors to Augment Growth.中性粒细胞胞外诱捕网驱动肿瘤中的线粒体稳态以增强生长。
Cancer Res. 2019 Nov 1;79(21):5626-5639. doi: 10.1158/0008-5472.CAN-19-0800. Epub 2019 Sep 13.
3
Adenosine receptor agonism protects against NETosis and thrombosis in antiphospholipid syndrome.腺苷受体激动剂可预防抗磷脂综合征中的 NETosis 和血栓形成。
Nat Commun. 2019 Apr 23;10(1):1916. doi: 10.1038/s41467-019-09801-x.
4
Neutrophil extracellular traps produced during inflammation awaken dormant cancer cells in mice.中性粒细胞胞外诱捕网在炎症期间产生，可唤醒小鼠体内休眠的癌细胞。
Science. 2018 Sep 28;361(6409). doi: 10.1126/science.aao4227.
5
Neutrophil extracellular traps in immunity and disease.中性粒细胞胞外陷阱在免疫和疾病中的作用。
Nat Rev Immunol. 2018 Feb;18(2):134-147. doi: 10.1038/nri.2017.105. Epub 2017 Oct 9.
6
Tumor-Induced NETosis as a Risk Factor for Metastasis and Organ Failure.肿瘤诱导的 NETosis 作为转移和器官衰竭的风险因素。
Cancer Res. 2016 Aug 1;76(15):4311-5. doi: 10.1158/0008-5472.CAN-15-3051. Epub 2016 Jul 11.
7
Eradication of metastatic mouse cancers resistant to immune checkpoint blockade by suppression of myeloid-derived cells.通过抑制髓系来源细胞消除对免疫检查点阻断有抗性的转移性小鼠肿瘤。
Proc Natl Acad Sci U S A. 2014 Aug 12;111(32):11774-9. doi: 10.1073/pnas.1410626111. Epub 2014 Jul 28.
8
Neutrophil extracellular traps sequester circulating tumor cells and promote metastasis.中性粒细胞胞外诱捕网捕获循环肿瘤细胞并促进转移。
J Clin Invest. 2013 Jul 1;123(8):3446-58. doi: 10.1172/JCI67484.
9
Cancers predispose neutrophils to release extracellular DNA traps that contribute to cancer-associated thrombosis.癌症使中性粒细胞易于释放细胞外 DNA 陷阱，从而导致与癌症相关的血栓形成。
Proc Natl Acad Sci U S A. 2012 Aug 7;109(32):13076-81. doi: 10.1073/pnas.1200419109. Epub 2012 Jul 23.
10
Neutrophil extracellular traps kill bacteria.中性粒细胞胞外诱捕网可杀死细菌。
Science. 2004 Mar 5;303(5663):1532-5. doi: 10.1126/science.1092385.
Zotero 插件