Carette Timothée, Mulquin Nicolas, van Pesch Vincent, London Frédéric
Department of Neurology, CHU UCL Namur site Godinne, Université catholique de Louvain (UCLouvain), Yvoir, Belgium.
Department of Radiology, CHU UCL Namur site Godinne, Université catholique de Louvain (UCLouvain), Yvoir, Belgium.
Mult Scler Relat Disord. 2021 Apr;49:102789. doi: 10.1016/j.msard.2021.102789. Epub 2021 Jan 22.
Paraneoplastic neurological syndromes (PNS) are immune-mediated complications of cancer associated with a broad spectrum of clinical manifestations. Optic neuropathy (ON) and myelitis are frequent manifestations of multiple sclerosis and neuromyelitis optic spectrum disorders but are considered as non-classical in PNS. Here, we report a case of PNS revealed by simultaneous bilateral ON and myelitis related to a cluster of three neural autoantibodies, in the setting of small cell lung cancer.
副肿瘤性神经系统综合征（PNS）是癌症相关的免疫介导并发症，具有广泛的临床表现。视神经病变（ON）和脊髓炎是多发性硬化症和视神经脊髓炎谱系障碍的常见表现，但在PNS中被认为是非典型的。在此，我们报告一例PNS病例，该病例表现为双侧ON和脊髓炎同时出现，与三种神经自身抗体相关，发生于小细胞肺癌患者。
