Fukushima Hirofumi, Shibuya Tomoyoshi, Awatsu Takahito, Kurosawa Taro, Haga Keiichi, Murakami Takashi, Serizawa Nobuko, Mori Akio, Hojo Mariko, Yao Takashi, Hattori Nobutaka, Nagahara Akihito
Department of Gastroenterology, Juntendo University School of Medicine, Japan.
Department of Neurology, Juntendo University School of Medicine, Japan.
Intern Med. 2022 May 15;61(10):1497-1501. doi: 10.2169/internalmedicine.8425-21. Epub 2021 Oct 19.
Paraneoplastic neurological syndrome (PNS) is a heterogeneous group of neurological disorders caused by immune-mediated inflammatory mechanisms. We herein report a 77-year-old man with CV2/CRMP5-antibody-related PNS associated with a gastrointestinal stromal tumor (GIST). He was admitted for forgetfulness and delusional behavior. His neurological symptoms were subacute, and a whole-body examination revealed a gastric GIST. Serology showed CV2/collapsin response mediator protein (CRMP)-5 antibodies. Partial gastrectomy was performed for the GIST, and the neurological symptoms and serum CV2/CRMP5 antibodies disappeared. No relapse has occurred since the surgery. PNS should be considered in patients with subacute neurological disorders.
副肿瘤性神经系统综合征（PNS）是一组由免疫介导的炎症机制引起的异质性神经系统疾病。我们在此报告一名77岁男性，患有与胃肠道间质瘤（GIST）相关的CV2/CRMP5抗体相关PNS。他因健忘和妄想行为入院。他的神经系统症状呈亚急性，全身检查发现胃GIST。血清学检查显示CV2/塌陷反应介导蛋白（CRMP）-5抗体。对GIST进行了部分胃切除术，神经系统症状和血清CV2/CRMP5抗体消失。术后未再复发。对于患有亚急性神经系统疾病的患者，应考虑PNS。
