Department of Gynecology and Obstetrics, Complejo Hospitalario Universitario Insular Materno-Infantil, Las Palmas de Gran Canaria, Spain.
Depatment of Radiotherapy, Hospital Dr. Negrin, Las Palmas de Gran Canaria, Spain.
Rev Bras Ginecol Obstet. 2021 Jan;43(1):41-45. doi: 10.1055/s-0040-1721352. Epub 2021 Jan 29.
The aim of the present study was to analyze relapse rates and patterns in patients with endometrial cancer with the aim of evaluating the effectiveness of current follow-up procedures in terms of patient survival, as well as the convenience of modifying the surveillance strategy.
Retrospective descriptive study including all patients diagnosed with endometrial cancer relapse at the Department of Gynecology and Obstetrics of the Complejo Hospitalario Insular-Materno Infantil de Canarias, between 2005 and 2014.
Recurrence was observed in 81 patients (10.04% of the sample); 66.7% of them suffered relapse within 2 years and 80.2% within 3 years after the termination of the primary treatment; 41.9% showed distant metastases while the rest corresponded to local-regional (40.7%) or ganglionar (17.4%) relapse; 42% of these were symptomatic; 14 patients showed more than 1 site of relapse. Relapse was detected mainly through symptoms and physical examination findings (54.3%), followed by elevated serum marker levels (29.6%), computed tomography (CT) images (9.9%) and abnormal vaginal cytology findings (6.2%). No differences in global survival were found between patients with symptomatic or asymptomatic relapse.
Taking into account that the recurrence rate of endometrial cancer is low, that relapse occurs mainly within the first 3 years post-treatment and that symptom evaluation and physical examination are the most effective follow-up methods, we postulate that a modification of the current model of hospital follow-up should be considered.
本研究旨在分析子宫内膜癌患者的复发率和模式，以评估当前随访程序在患者生存方面的有效性，以及修改监测策略的便利性。
回顾性描述性研究，包括 2005 年至 2014 年期间在加那利群岛综合医院妇产科诊断为子宫内膜癌复发的所有患者。
81 例患者（样本的 10.04%）观察到复发；其中 66.7%在原发性治疗结束后 2 年内复发，80.2%在 3 年内复发；41.9%出现远处转移，其余为局部-区域（40.7%）或淋巴结（17.4%）复发；42%的患者有症状；14 例患者有多个复发部位。复发主要通过症状和体格检查发现（54.3%），其次是血清标志物水平升高（29.6%）、计算机断层扫描（CT）图像（9.9%）和异常阴道细胞学发现（6.2%）。有症状或无症状复发患者的总体生存率无差异。
考虑到子宫内膜癌的复发率较低，复发主要发生在治疗后 3 年内，且症状评估和体格检查是最有效的随访方法，我们推测应考虑修改当前的医院随访模式。
