Kikuchi Y, Oomori K, Kizawa I, Kita T, Miyauchi M, Iwano I, Kato K
Department of Obstetrics and Gynecology, National Defense Medical College, Saitama.
Nihon Sanka Fujinka Gakkai Zasshi. 1988 Jan;40(1):81-6.
The present study was designed to potentiate the antitumor effects of cisplatin by combination with calmodulin antagonists (W-7 and W-5) by using nude mice bearing human ovarian carcinoma. Tumor growth in nude mice treated with W-7 or W-5 combined with cisplatin was significantly inhibited, compared to that in nude mice treated with W-7 alone, W-5 alone or cisplatin alone. Although treatment with cisplatin alone markedly inhibited lytic activity of the spleen cells from tumor bearing nude mice against the tumor cells, the inhibitory effect was eliminated by combination with W-7 or W-5. There was no significant difference in the survival time among untreated, cisplatin-treated, W-7-treated and W-5-treated groups. Only when cisplatin was followed by W-7 or W-5, a significant enhancement by W-7 or W-5 of the antitumor effect of cisplatin was observed with respect to inhibition of the tumor growth as well as prolongation of the survival time.
本研究旨在通过将顺铂与钙调蛋白拮抗剂（W - 7和W - 5）联合使用，增强其对人卵巢癌裸鼠的抗肿瘤作用。与单独使用W - 7、单独使用W - 5或单独使用顺铂处理的裸鼠相比，用W - 7或W - 5联合顺铂处理的裸鼠肿瘤生长受到显著抑制。尽管单独使用顺铂可显著抑制荷瘤裸鼠脾细胞对肿瘤细胞的溶解活性，但与W - 7或W - 5联合使用后，这种抑制作用被消除。未处理组、顺铂处理组、W - 7处理组和W - 5处理组的生存时间无显著差异。只有当顺铂之后使用W - 7或W - 5时，才观察到W - 7或W - 5在抑制肿瘤生长以及延长生存时间方面对顺铂抗肿瘤作用有显著增强。
