Slootweg M C, van Buul-Offers S C, Herrmann-Erlee M P, van der Meer J M, Duursma S A
University Hospital, Department of Internal Medicine, Utrecht, The Netherlands.
J Endocrinol. 1988 Mar;116(3):R11-3. doi: 10.1677/joe.0.116r011.
More evidence has recently been obtained indicating that growth hormone (GH) has a direct effect on bone. However, it is not clear which cell type reacts to the hormone. The present study used osteoblast-like cells derived from sequentially digested fetal mouse calvaria. Separately cultured tractions resulted in populations enriched in cells with a more or a less differentiated phenotype. The results showed that GH acts on the cells released last, i.e. those with more characteristics of the osteoblast. In these cells, GH induced strong mitogenic activity. Prolactin was not active.
最近获得了更多证据，表明生长激素（GH）对骨骼有直接作用。然而，尚不清楚哪种细胞类型对该激素有反应。本研究使用了从连续消化的胎鼠颅骨中获得的成骨细胞样细胞。分别培养的细胞群导致富含具有或多或少分化表型细胞的群体。结果表明，GH作用于最后释放的细胞，即那些具有更多成骨细胞特征的细胞。在这些细胞中，GH诱导强烈的促有丝分裂活性。催乳素没有活性。
