Department of Geriatric, the First Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510080, PR China.
Department of Cardiology, the First Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510080, PR China; NHC Key Laboratory of Assisted Circulation, Sun Yat-sen University, Guangzhou 510080, PR China; National-Guangdong Joint Engineering Laboratory for Diagnosis and Treatment of Vascular, Diseases, Guangzhou, PR China.
J Diabetes Complications. 2021 Apr;35(4):107833. doi: 10.1016/j.jdiacomp.2020.107833. Epub 2021 Jan 2.
Individuals with diabetes have a high risk of cardiovascular disease (CVD). However, the association between type 1 diabetes mellitus (T1DM) and the risk of CVD has not been well addressed. This meta-analysis aimed to investigate the association between T1DM and CVD.
We searched the PubMed and EMBASE for studies that examined the association between T1DM and CVD until October 2020. We calculated the pooled risk ratios (RRs) with confidence intervals (CIs) from individual studies based on a random-effects model.
We included 10 observational studies involving 166,027 patients with T1DM, and individuals were matched controls from the general population. Among T1DM patients, the RR of CVD was 5.09 (95% CI, 3.72-6.96), of coronary heart disease (CHD) was 9.38 (95% CI, 5.56-15.82), and of myocardial infarction was 6.37 (95% CI, 3.81-10.66). The RR of heart failure was 4.29 (95% CI, 3.54-5.19), of atrial fibrillation was 1.36 (95% CI, 1.17-1.59), and of stroke was 4.08 (95% CI, 3.42-4.86). Moreover, there was an increased RR among females for CHD, CVD, myocardial infarction, and stroke associated with T1DM.
This study suggests that T1DM is associated with an increased risk of several types of CVD. However, the possible mechanisms for the increased risk of CVD remain unclear.
患有糖尿病的个体患心血管疾病（CVD）的风险较高。然而，1 型糖尿病（T1DM）与 CVD 风险之间的关系尚未得到很好的解决。本荟萃分析旨在研究 T1DM 与 CVD 之间的关系。
我们检索了 PubMed 和 EMBASE，以查找截至 2020 年 10 月检查 T1DM 与 CVD 之间关系的研究。我们根据随机效应模型从单个研究中计算出合并的风险比（RR）及其置信区间（CI）。
我们纳入了 10 项观察性研究，涉及 166,027 例 T1DM 患者和来自普通人群的个体匹配对照。在 T1DM 患者中，CVD 的 RR 为 5.09（95%CI，3.72-6.96），冠心病（CHD）为 9.38（95%CI，5.56-15.82），心肌梗死为 6.37（95%CI，3.81-10.66）。心力衰竭的 RR 为 4.29（95%CI，3.54-5.19），心房颤动为 1.36（95%CI，1.17-1.59），中风为 4.08（95%CI，3.42-4.86）。此外，与 T1DM 相关的女性 CHD、CVD、心肌梗死和中风的 RR 增加。
本研究表明，T1DM 与多种 CVD 风险增加相关。然而，CVD 风险增加的可能机制尚不清楚。
