Vestibular and Ocular Motor Research Group, Department of Neuroscience, Erasmus MC, Rotterdam, The Netherlands.
Medical and Vision Research Foundation, Chennai, India.
Sci Rep. 2021 Jan 29;11(1):2630. doi: 10.1038/s41598-021-81762-y.
In eye movement perimetry (EMP), the saccadic reaction time (SRT) to 'seen' visual stimuli are delayed in glaucoma. Evaluating SRT behaviour in hemi-field sectors could refine its clinical implication. The development phase included 60 controls retrospectively and for the test cohort in evaluation phase, another 30 healthy subjects and 30 glaucoma patients were recruited prospectively. The SRTs were used to calculate the normative limits within 5 predefined hemi-field sectors. Scores were assigned to probabilities for SRT at the level of 5%, 2.5% 1% and 0.5%. Per sector pair, a probability score limit (PSL) was calculated at each of the four levels and were compared with the scores obtained from the test cohort. The classification accuracy 'normal versus abnormal' was assessed for PSL in EMP and compared with glaucoma hemi-field test in standard automated perimetry. We found no statistically significant differences in SRTs between the mirror sectors in healthy subjects. The PSL at 2.5% had moderate classification accuracy with a specificity of 77% and sensitivity 70%. This could be suggestive of an SRT delay in the overall visual field in glaucoma.
在眼动视野检查（EMP）中，青光眼患者对“看到”的视觉刺激的眼跳反应时间（SRT）会延迟。评估半视野区域的 SRT 行为可以细化其临床意义。开发阶段包括 60 名回顾性对照和评估阶段的 30 名健康受试者和 30 名青光眼患者。使用 SRT 计算 5 个预设半视野区域内的正常范围。分数分配给 SRT 在 5%、2.5%、1%和 0.5%水平的概率。在每个四个水平下，计算了每个区域对的概率得分限值（PSL），并与测试队列的得分进行了比较。使用 EMP 中的 PSL 评估“正常与异常”的分类准确性，并与标准自动视野计中的青光眼半视野测试进行比较。我们发现健康受试者的镜像区域之间的 SRT 没有统计学上的显著差异。在 2.5%的 PSL 具有中等的分类准确性，特异性为 77%，敏感性为 70%。这可能表明青光眼的整个视野存在 SRT 延迟。
