Department of Cardiology, Aalborg University Hospital, 9000, Aalborg, Denmark.
Department of Clinical Medicine, Aalborg University, 9000, Aalborg, Denmark.
Eur J Clin Nutr. 2021 Oct;75(10):1483-1490. doi: 10.1038/s41430-021-00858-w. Epub 2021 Jan 29.
A high intake of marine n-3 polyunsaturated fatty acids (PUFAs) may lower the risk of coronary heart disease and ischemic stroke. The association between intake of marine n-3 PUFAs and development of peripheral artery disease (PAD), however, remains unexplored. We hypothesised that intake of marine n-3 PUFAs, eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA) and the sum of EPA + DHA was associated with a lower risk of incident PAD.
We used data from the Danish Diet, Cancer and Health cohort and investigated the associations between intake of EPA, DHA and EPA + DHA and development of PAD. Information on intake of n-3 PUFAs was obtained through a validated food frequency questionnaire. Potential PAD cases were identified through linkage to the Danish National Patient Register and subsequently, all cases were validated.
Data were available from 55,248 participants and during a median of 13.6 years of follow-up, 950 cases of PAD were identified. Multivariate Cox regression analyses with adjustments for established risk factors showed no statistically significant associations between intake of EPA (p = 0.255), DHA (p = 0.071) or EPA + DHA (p = 0.168) and the rate of incident PAD.
We did not confirm our hypothesis that intake of EPA, DHA or EPA + DHA was associated with a lower risk of incident PAD.
大量摄入海洋 n-3 多不饱和脂肪酸（PUFA）可能降低冠心病和缺血性中风的风险。然而，海洋 n-3 PUFAs 摄入量与外周动脉疾病（PAD）发展之间的关系尚未得到探索。我们假设摄入海洋 n-3 PUFAs、二十碳五烯酸（EPA）、二十二碳六烯酸（DHA）和 EPA+DHA 的总和与 PAD 发病风险降低有关。
我们使用丹麦饮食、癌症和健康队列的数据，研究了 EPA、DHA 和 EPA+DHA 的摄入量与 PAD 发病之间的关系。通过验证的食物频率问卷获得 n-3 PUFAs 的摄入量信息。通过与丹麦国家患者登记处的链接识别潜在的 PAD 病例，随后对所有病例进行验证。
数据来自 55248 名参与者，在中位数为 13.6 年的随访期间，共确定了 950 例 PAD 病例。经过调整已知危险因素的多变量 Cox 回归分析显示，EPA（p=0.255）、DHA（p=0.071）或 EPA+DHA（p=0.168）的摄入量与 PAD 的发病速率之间没有统计学上的显著关联。
我们没有证实我们的假设，即摄入 EPA、DHA 或 EPA+DHA 与降低 PAD 的发病风险有关。
