Cheng Yaru, Lu Huiting, Yang Fan, Zhang Yiyi, Dong Haifeng
Research Center for Bioengineering and Sensing Technology, School of Chemistry and Bioengineering, University of Science & Technology Beijing, 30 Xueyuan Road, Beijing 100083, P. R. China.
Nanoscale. 2021 Feb 7;13(5):3049-3060. doi: 10.1039/d0nr07215j. Epub 2021 Jan 29.
The development of a simple and effective single constituent multifunctional nanotheranostic platform producing a multimodality diagnostic signal and curing effect is still a challenge. Herein, we synthesized simple and biodegradable FeWO ternary oxide nanoparticles and modified their surface with RGD-PEG-NH (FeWO-PEG-RGD NPs), whereby resulting NPs possessed a (T/T) switchable MRI/CT dual-modal imaging ability and synergistic photothermal therapy (PTT)/photodynamic therapy (PDT)/chemodynamic therapy (CDT) capacity. We showed that FeWO-PEG-RGD NPs enabled tumor accumulation under a magnetic field drive and RGD-mediated tumor penetration and implemented PTT/PDT treatment under 980 nm laser irradiation. In an acidic tumor microenvironment (TME) with a high hydrogen peroxide (HO) expression, NPs degraded to release Fe and Fe, triggering a Fenton reaction to generate ˙OH for CDT. The released Fe led to T/T signal conversion for tracing cancer therapy, while the high X-ray attenuation coefficient of W also made it a good CT contrast agent for guided therapy. Thus, the structurally simple FeWO-PEG-RGD was capable of mediating (T/T-weighted) MR/CT two modal imaging-guided PTT/PDT/CDT synergic therapy with a high accuracy and superb anticancer efficiency. The simple, degradable, rapid-clearance, and multifunctional FeWO-PEG-RGD NPs provide a novel, promising, and versatile nanotheranostic platform.
开发一种简单有效的单组分多功能纳米诊疗平台，使其产生多模态诊断信号并具备治疗效果，仍然是一项挑战。在此，我们合成了简单且可生物降解的钨酸铁三元氧化物纳米颗粒，并用RGD-PEG-NH对其表面进行修饰（FeWO-PEG-RGD纳米颗粒），由此得到的纳米颗粒具有（T/T）可切换的MRI/CT双模态成像能力以及协同光热疗法（PTT）/光动力疗法（PDT）/化学动力疗法（CDT）能力。我们表明，FeWO-PEG-RGD纳米颗粒能够在磁场驱动下实现肿瘤蓄积以及RGD介导的肿瘤渗透，并在980 nm激光照射下实施PTT/PDT治疗。在具有高过氧化氢（HO）表达的酸性肿瘤微环境（TME）中，纳米颗粒降解以释放Fe和Fe，引发芬顿反应以生成用于CDT的˙OH。释放的Fe导致T/T信号转换以追踪癌症治疗，而W的高X射线衰减系数也使其成为用于引导治疗的良好CT造影剂。因此，结构简单的FeWO-PEG-RGD能够介导（T/T加权）MR/CT双模态成像引导的PTT/PDT/CDT协同治疗，具有高精度和卓越的抗癌效率。这种简单、可降解、快速清除且多功能的FeWO-PEG-RGD纳米颗粒提供了一种新颖、有前景且通用的纳米诊疗平台。
