Key Laboratory of Functional Nanomaterials and Technology in Universities of Shandong, College of Chemistry and Chemical Engineering, Linyi University, Linyi, 276000, P. R. China.
College of Chemical and Environmental Engineering, Shandong University of Science and Technology, Qingdao, 266590, P. R. China.
Adv Healthc Mater. 2020 Nov;9(21):e1901634. doi: 10.1002/adhm.201901634. Epub 2020 Sep 21.
Multimodal imaging-guided synergistic anticancer strategies have attracted increasing attention for efficient diagnosis and therapy of cancer. Herein, a multifunctional nanotheranostic agent FePtMn-Ce6/FA (FPMCF NPs) is constructed by covalently anchoring photosensitizer chlorin e6 (Ce6) and targeting molecule folic acid (FA) on ultrasmall homogeneous ternary FePtMn nanocrystals. Response to tumor microenvironment (TME), FPMCF NPs can release Fe to catalyze H O into •OH by Fenton reaction and simultaneously catalyze hydrogen peroxide (H O ) into O to overcome the tumor hypoxia barrier. Released O is further catalyzed into O under 660 nm laser irradiation with Ce6. Thus, the FPMCF NPs exhibit superior dual-ROS oxidization capability including ferroptosis chemodynamic oxidization and O -based photodynamic oxidization. Interestingly, FPMCF NPs reveal strong photothermal conversion efficiency exposed to an 808 nm laser, which can assist dual-ROS oxidization to suppress solid tumor remarkably. Additionally, Mn can be released from FPMCF NPs to enhance longitudinal relaxivity (T -weighted magnetic resonance (MR) imaging) and Fe-synergistic transverse relaxivity (T -weighted MR imaging), which is convenient for diagnosis of solid tumors. Meanwhile, the fluorescent/photothermal (FL/PT) imaging function of FPMCF NPs can also accurately monitor tumor location. Therefore, FPMCF NPs with multimodal MR/FL/PT imaging-guided synergistic chemodynamic/photodynamic/photothermal cancer therapy capability have potential bioapplication in bionanomedicine field.
多模态影像引导的协同抗癌策略因其在癌症的高效诊断和治疗方面的优势而受到越来越多的关注。在此，通过将光敏剂氯代叶绿素 e6（Ce6）和靶向分子叶酸（FA）共价锚定在超小均一的三元 FePtMn 纳米晶上，构建了一种多功能的纳米诊疗剂 FePtMn-Ce6/FA（FPMCF NPs）。响应肿瘤微环境（TME），FPMCF NPs 可以释放 Fe 并通过芬顿反应将 H2O2 催化生成•OH，同时还可以催化 H2O2 生成 O2 以克服肿瘤缺氧屏障。在 660nm 激光照射下，释放的 O2 与 Ce6 进一步反应生成 1O2。因此，FPMCF NPs 表现出卓越的双重 ROS 氧化能力，包括铁死亡化学动力学氧化和 1O2 基光动力氧化。有趣的是，FPMCF NPs 在暴露于 808nm 激光时表现出很强的光热转换效率，可辅助双重 ROS 氧化显著抑制实体瘤。此外，Mn 可以从 FPMCF NPs 中释放出来，增强纵向弛豫率（T1 加权磁共振（MR）成像）和 Fe 协同的横向弛豫率（T2 加权 MR 成像），便于实体瘤的诊断。同时，FPMCF NPs 的荧光/光热（FL/PT）成像功能也可以准确监测肿瘤位置。因此，FPMCF NPs 具有多模态磁共振/荧光/光热成像引导的协同化学动力学/光动力/光热癌症治疗能力，在生物医学领域具有潜在的应用前景。
