Parkhouse N, Le Quesne P M
Department of Surgical Studies, Middlesex Hospital Medical School, London, UK.
J Neurol Neurosurg Psychiatry. 1988 Jan;51(1):28-34. doi: 10.1136/jnnp.51.1.28.
A technique is described for the quantitative assessment of peripheral nociceptive C fibre function by measurement of the axon reflex flare. Acetylcholine, introduced by electrophoresis, is used to stimulate a ring of nociceptive C fibre endings at the centre of which the increase in blood flow is measured with a laser Doppler flowmeter. This flare (neurogenic vasodilatation) has been compared with mechanically or chemically stimulated non-neurogenic cutaneous vasodilation. The flare is abolished by local anaesthetic and is absent in denervated skin. The flare has been measured on the sole of the foot of 96 healthy subjects; its size decreases with age in males, but not in females.
本文描述了一种通过测量轴突反射性潮红来定量评估外周伤害性C纤维功能的技术。通过电泳引入乙酰胆碱，用于刺激一圈伤害性C纤维末梢，在其中心用激光多普勒血流仪测量血流增加情况。这种潮红（神经源性血管舒张）已与机械或化学刺激引起的非神经源性皮肤血管舒张进行了比较。局部麻醉可消除潮红，去神经支配的皮肤中则不存在潮红。已对96名健康受试者的脚底进行了潮红测量；男性的潮红大小随年龄增长而减小，女性则不然。
