我们是否正处于生物学新纪元的边缘？分子发育生物学的不合逻辑与通过分化波对胚胎发生的两面性控制。

Are we on the cusp of a new paradigm for biology? The illogic of molecular developmental biology versus Janus-faced control of embryogenesis via differentiation waves.

机构信息

Gulf Specimen Marine Laboratory & Aquarium, 222 Clark Drive, Panacea, FL, 32346, USA; C.S. Mott Center for Human Growth & Development, Department of Obstetrics & Gynecology, Wayne State University, 275 E. Hancock, Detroit, MI, 48201, USA.

出版信息

Biosystems. 2021 May;203:104367. doi: 10.1016/j.biosystems.2021.104367. Epub 2021 Jan 28.

DOI:10.1016/j.biosystems.2021.104367

PMID:33515641

Abstract

The logic of molecular developmental biology fails to explain embryogenesis. A new approach, Janus-faced control, involving both top-down control by differentiation waves and bottom-up control via the mechanical consequences of cell differentiations, may be needed. This obviates problems inherent in reductionism with an explicit, testable mechanism.

摘要

分子发育生物学的逻辑无法解释胚胎发生。一种新的方法，两面神控制，涉及通过分化波的自上而下的控制和通过细胞分化的机械后果的自下而上的控制，可能是必要的。这避免了还原论所固有的问题，并提供了一个明确的、可测试的机制。