School of food science and pharmaceutical engineering, Testing & Analysis Center, Nanjing Normal University, Nanjing 210023, People's Republic of China.
Jiangsu Key Laboratory of Bioactive Natural Product Research and State Key Laboratory of Natural Medicines, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing 210009, People's Republic of China; Department of Pharmaceutical Engineering, Jiangsu Provincial Xuzhou Pharmaceutical Vocational college, Xuzhou 221116, People's Republic of China.
Fitoterapia. 2021 Apr;150:104838. doi: 10.1016/j.fitote.2021.104838. Epub 2021 Jan 28.
Vernoramyosides A-F (1-6), six new Δ stigmastane-type steroid saponins, along with four known analogues (7-10) were isolated from the leaves of Vernonia amygdalina Delile (Compositae). Their structures were determined by the combination of NMR, ECD and HR-ESI-MS data. These compounds all possessed highly oxidized side chain and a γ-lactam or α,β-unsaturated five-membered lactone ring. All isolates were screened for their activities in reversing resistance in MCF/DOX cells.
从马缨丹（Compositae）的叶子中分离得到 Vernoramyosides A-F（1-6），这是六种新的Δ甾烷型甾体皂苷，以及四种已知类似物（7-10）。通过 NMR、ECD 和 HR-ESI-MS 数据的组合确定了它们的结构。这些化合物都具有高度氧化的侧链和γ-内酰胺或α,β-不饱和五元内酯环。所有分离物都进行了筛选，以检测它们在逆转 MCF/DOX 细胞耐药性方面的活性。
