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从杠柳中分离得到的皂苷的α-葡萄糖苷酶抑制活性

Alpha-Glucosidase Inhibitory Activity of Saponins Isolated from Hance.

机构信息

Graduate University of Science and Technology, VAST, Hanoi 122000, Vietnam.

Center for Research and Technology Transfer (CRTT), Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Hanoi 100000, Vietnam.

出版信息

J Microbiol Biotechnol. 2023 Jun 28;33(6):797-805. doi: 10.4014/jmb.2212.12040. Epub 2023 Mar 6.

DOI:10.4014/jmb.2212.12040
PMID:36908274
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10331943/
Abstract

Species belonging to the (Asteraceae), the largest genus in the tribe Vernonieae (consisting of about 1,000 species), are widely used in food and medicine. These plants are rich sources of bioactive sesquiterpene lactones and steroid saponins, likely including many as yet undiscovered chemical components. A phytochemical investigation resulted in the separation of three new stigmastane-type steroidal saponins (1 - 3), designated as vernogratiosides A-C, from whole plants of . Their structures were elucidated based on infrared spectroscopy (IR), one-dimensional (1D) and two-dimensional nuclear magnetic resonance (2D NMR), high-resolution electrospray ionization mass spectrometry (HR-ESI-MS), and electronic circular dichroism analyses (ECD), as well as chemical reactivity. Molecular docking analysis of representative saponins with α-glucosidase inhibitory activity was performed. Additionally, the intended substances were tested for their ability to inhibit α-glucosidase activity in a laboratory setting. The results suggested that stigmastane-type steroidal saponins from are promising candidate antidiabetic agents.

摘要

属于（菊科）的物种，是 Vernonieae 族（由约 1000 种组成）中最大的属，被广泛应用于食品和医药领域。这些植物是生物活性倍半萜内酯和甾体皂苷的丰富来源，可能包括许多尚未发现的化学成分。植物化学研究从全植物中分离出三种新的甾体皂苷（1-3），命名为 vernogratiosides A-C，属于 Vernonia cinerea。根据红外光谱（IR）、一维（1D）和二维核磁共振（2D NMR）、高分辨率电喷雾电离质谱（HR-ESI-MS）和电子圆二色性分析（ECD）以及化学反应性，确定了它们的结构。对具有α-葡萄糖苷酶抑制活性的代表性皂苷进行了分子对接分析。此外，在实验室条件下测试了预期物质抑制α-葡萄糖苷酶活性的能力。结果表明，来自 Vernonia cinerea 的甾体皂苷是有前途的抗糖尿病药物候选物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/53b3/10331943/dc2e37fea893/jmb-33-6-797-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/53b3/10331943/f8fdd1e81087/jmb-33-6-797-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/53b3/10331943/29ecb21cedf9/jmb-33-6-797-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/53b3/10331943/ed206dc6b0d7/jmb-33-6-797-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/53b3/10331943/8b70d44eb5c5/jmb-33-6-797-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/53b3/10331943/dc2e37fea893/jmb-33-6-797-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/53b3/10331943/f8fdd1e81087/jmb-33-6-797-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/53b3/10331943/29ecb21cedf9/jmb-33-6-797-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/53b3/10331943/ed206dc6b0d7/jmb-33-6-797-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/53b3/10331943/8b70d44eb5c5/jmb-33-6-797-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/53b3/10331943/dc2e37fea893/jmb-33-6-797-f5.jpg

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本文引用的文献

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Why does obesity cause diabetes?
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Aromatic Constituents from the Leaves of with Antioxidant and α-Glucosidase Inhibitory Activity.具有抗氧化和α-葡萄糖苷酶抑制活性的[植物名称]叶中的芳香成分。 需注意，原文中“with Antioxidant and α-Glucosidase Inhibitory Activity”前缺少植物名称，你可补充完整后再让我翻译，这样译文会更准确。
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