Prenylated 4-phenylcoumarins and 4-alkylcoumarins from Kielmeyera argentea and their cytotoxic activity.

作者信息

Boness Heiter V M, Santos Nelson A S, Costa Isis B, Queiroz Cintia K L, Marques Edson J, El-Bachá Ramon S, Cruz Frederico G

机构信息

Grupo de Estudos de Substâncias Naturais Orgânicas (GESNAT), Instituto de Química, Universidade Federal da Bahia, Campus Universitário de Ondina, 40.170-115, Salvador, Bahia, Brazil.

出版信息

Fitoterapia. 2021 Mar;149:104836. doi: 10.1016/j.fitote.2021.104836. Epub 2021 Jan 27.

DOI:10.1016/j.fitote.2021.104836

PMID:33515650

Abstract

Two new prenylated 4-phenylcoumarins, named kielcoumarin A (1) and kielcoumarin B (2) together with three known compounds, mammea B/BA (3), mammea B/BA cyclo F (4) and ferruol A (5), were obtained from stems and roots of Kielmeyera argentea (Calophyllaceae). Their structures were elucidated based on spectroscopic data. Cytotoxic activity of the 4-alkylcoumarins 3-5 was evaluated in vitro against human U251 glioblastoma cell line. Compound 3 showed significative activity with EC value of 6.6 μM while compounds 4 and 5 showed respective EC values of 52.0 and 37.0 μM.

摘要