Unité de Biologie et Pathogénicité Fongiques, Institut Pasteur, INRA USC2019, Paris, 75015, France.
Res Microbiol. 2021 Apr-May;172(3):103813. doi: 10.1016/j.resmic.2021.103813. Epub 2021 Jan 28.
Candida species represent a major fungal threat for human health. Within the Candida genus, the yeast Candida albicans is the most frequently incriminated species during episodes of candidiasis or candidemia. Biofilm formation is used by C. albicans to produce a microbial community that is important in an infectious context. The cell wall, the most superficial cellular compartment, is of paramount importance regarding the establishment of biofilms. C. albicans cell wall contains proteins with amyloid properties that are necessary for biofilm formation due to their adhesion properties. This review focuses on these amyloid proteins during biofilm formation in the yeast C. albicans.
念珠菌属物种是人类健康的主要真菌威胁。在念珠菌属中，白色念珠菌是念珠菌病或念珠菌血症发作时最常被归咎的物种。生物膜的形成被白色念珠菌用于产生微生物群落，这在感染情况下非常重要。细胞壁是最表面的细胞区室，对于生物膜的形成至关重要。白色念珠菌细胞壁含有具有淀粉样特性的蛋白质，由于其粘附特性，这些蛋白质对于生物膜的形成是必需的。这篇综述主要关注酵母白色念珠菌生物膜形成过程中的这些淀粉样蛋白。
