Ko Da Pharmaceutical Co. Ltd., Taoyuan city, Taiwan.
Ko Da Pharmaceutical Co. Ltd., Taoyuan city, Taiwan; Graduate Institute of Pharmacognosy, Taipei Medical University, Taipei, Taiwan.
J Hazard Mater. 2021 Jun 15;412:125142. doi: 10.1016/j.jhazmat.2021.125142. Epub 2021 Jan 23.
The content of toxic heavy metals (THMs), including lead (Pb), arsenic (As), cadmium (Cd), and mercury (Hg), was determined in a total of 10,245 samples for 279 types of Chinese herbal medicine (CHM) using a validated inductively coupled plasma mass spectrometry method. The exceeding rate (ER) for the four THMs were calculated based on diverse permissible limits (PLs) established by different organizations and national pharmacopeias. Cluster analysis was used to classify the degree risk of THMs contamination according to the calculated ER. Results revealed that Cibotii rhizome, Selaginellae herba, Morindae officinalis radix, Asprellae ilicis radix, and Toxicodendri resina exhibited high-degree risk of Pb contamination. Eckloniae/Laminariae thallus, Spirodelae herba, and Naturalis indigo possessed high-degree risk of As contamination. Tetrapanacis medulla, Centipedae herba, Cyathulae radix, Linderae radix, Meretricis/Cyclinae concha, and Tabanus displayed high-degree risk of Cd contamination. Toxicodendri resina has high-degree risk of Hg contamination. In addition, six types of CHM, including Asprellae ilicis radix, Toxicodendri resina, Eckloniae/Laminariae thallus, Fossilia Ossis Mastodi, Haematitum, and Hedyotidis diffusae herba, may have non-carcinogenic health risk after consumption of raw materials because the calculated hazard quotient and hazard index were over 1.0. In summary, these data provide useful information about THMs contamination in CHM.
采用经验证的电感耦合等离子体质谱法，对 279 种中药材的 10245 个样本进行了有毒重金属（THMs）含量（包括铅（Pb）、砷（As）、镉（Cd）和汞（Hg））测定。根据不同组织和国家药典制定的多种允许限量（PL），计算了这四种 THMs 的超标率（ER）。根据计算的 ER，采用聚类分析对 THMs 污染程度的风险进行分类。结果表明，白蔹、卷柏、巴戟天、青黛和五倍子的 Pb 污染程度为高度风险。昆布、螺旋藻和青黛的 As 污染程度为高度风险。刺五加、全蝎、川木通、乌药、海螵蛸和石决明的 Cd 污染程度为高度风险。五倍子的 Hg 污染程度为高度风险。此外，包括青黛、五倍子、昆布、龙骨、自然铜、虎杖在内的 6 种中药材，由于计算出的危害商和危害指数均超过 1.0，因此在食用原材料后可能存在非致癌健康风险。总之，这些数据为中药材中 THMs 污染情况提供了有用的信息。
