Division of Cardiology, Department of Medicine, University of Illinois at Chicago, 820 S Wood Street, Suite 920S, Chicago, IL 60612, USA; Division of Cardiology, Department of Pharmacology, University of Illinois at Chicago, 820 S Wood Street, Suite 920S, Chicago, IL 60612, USA.
Division of Cardiology, Department of Medicine, University of Illinois at Chicago, 820 S Wood Street, Suite 920S, Chicago, IL 60612, USA; Division of Cardiology, Department of Pharmacology, University of Illinois at Chicago, 820 S Wood Street, Suite 920S, Chicago, IL 60612, USA; Department of Medicine, Jesse Brown Veterans Administration, 820 S Wood Street, Suite 920S, Chicago, IL 60612, USA.
Card Electrophysiol Clin. 2021 Mar;13(1):155-163. doi: 10.1016/j.ccep.2020.10.004. Epub 2021 Jan 8.
Atrial fibrillation (AF), the common sustained arrhythmia in clinical practice, has major public health implications due to its associated morbidity and increased mortality. The AF epidemic is due to the burgeoning elderly population and the identification of novel risk factors, for example, genetics. Since the diagnosis of AF has a major impact on the clinical assessment and management of patients with inherited arrhythmia syndromes, improved understanding of the cause and pathogenesis of AF has provided important insights into the underlying pathophysiological mechanisms of this common arrhythmia and identified potential mechanism-based therapies.
心房颤动（AF）是临床实践中常见的持续性心律失常，由于其相关的发病率和死亡率增加，具有重大的公共卫生意义。AF 流行是由于老年人口的增加和新的危险因素的出现，例如遗传因素。由于 AF 的诊断对遗传性心律失常综合征患者的临床评估和治疗有重大影响，因此，对 AF 病因和发病机制的深入了解为这种常见心律失常的潜在病理生理机制提供了重要的见解，并确定了潜在的基于机制的治疗方法。
