Kaneko Yoshiyuki, Suzuki Masahiro, Ishihara Masaki, Kitamura Masayuki, Bando Shino, Sagawa Tomoaki, Yamada Kouju, Kubo Hideyuki, Nakajima Hideto, Uchiyama Makoto
Department of Psychiatry, Nihon University School of Medicine, Tokyo, Japan.
Department of Psychiatry, Nihon University School of Medicine, Tokyo, Japan.
Wilderness Environ Med. 2021 Mar;32(1):88-91. doi: 10.1016/j.wem.2020.10.006. Epub 2021 Jan 27.
We report a case of prolonged motivational deficit as a sequela of high altitude cerebral edema (HACE), the most severe form of neuropsychiatric dysfunction arising from traveling to high altitude. Magnetic resonance imaging of the brain showed hyperintense lesions in the globi pallidi bilaterally on T2-weighted images. Single-photon emission computed tomography showed hypoperfusion in dorsolateral and orbital prefrontal cortices bilaterally and in the anterior cingulate cortex. This case suggests that a prolonged motivational deficit can occur in patients with HACE. The case may also suggest that HACE can cause network disturbances between the prefrontal cortex and the globi pallidi.
我们报告一例长期动机缺乏作为高原脑水肿（HACE）后遗症的病例，HACE是前往高海拔地区引发的最严重的神经精神功能障碍形式。脑部磁共振成像显示，在T2加权图像上双侧苍白球出现高信号病变。单光子发射计算机断层扫描显示双侧背外侧和眶额前皮质以及前扣带回皮质灌注不足。该病例表明，HACE患者可能会出现长期动机缺乏。该病例还可能表明，HACE可导致前额叶皮质与苍白球之间的网络紊乱。
