联合脉冲氙紫外线消毒和末端手动清洁有助于降低耐甲氧西林金黄色葡萄球菌的获得率。

Combining pulsed xenon ultraviolet disinfection with terminal manual cleaning helps reduce the acquisition rate of methicillin-resistant Staphylococcus aureus.

机构信息

Project Research Center for Nosocomial Infectious Diseases, Hiroshima University, Hiroshima, Japan; Department of Infectious Diseases, Hiroshima University Hospital, Hiroshima, Japan; Department of Surgery, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan.

Department of Infection Control, Hiroshima University Hospital, Hiroshima, Japan; Department of Nursing, Hiroshima University Hospital, Hiroshima, Japan.

出版信息

Am J Infect Control. 2021 Aug;49(8):1048-1051. doi: 10.1016/j.ajic.2021.01.019. Epub 2021 Jan 29.

DOI:10.1016/j.ajic.2021.01.019

PMID:33516751

Abstract

BACKGROUND

The clinical effectiveness of ultraviolet light (UV) disinfection remains unclear. This study aimed to investigate the effect of adding pulsed xenon UV (PX-UV) disinfection to the terminal cleaning protocol on the rate of methicillin-resistant Staphylococcus aureus (MRSA) acquisition at a Japanese hospital.

METHODS

The use of a PX-UV disinfection device was added to the manual terminal cleaning protocol applied after the discharge or transfer of patients treated in the intensive and high care units. We used a Poisson regression model to examine the incidence of MRSA acquisition, based on the study period, PX-UV intervention status, unit type, and the rate of consumption of alcohol-based hand rub (ABHR).

RESULTS

Approximately 86% of the rooms in the intervention units were terminally disinfected with the PX-UV device. In the intervention units, the incidence of MRSA acquisition decreased from 3.56 per 1,000 patient-days in the nonintervention period to 2.21 per 1,000 patient-days in the intervention period. Moreover, the use of PX-UV disinfection decreased the risk of MRSA acquisition (incident rate ratio: 0.556; 95% confidence interval, 0.309-0.999; P = .0497). ABHR consumption did not affect the risk of MRSA acquisition.

CONCLUSIONS

Adding PX-UV disinfection to terminal manual cleaning reduced the rate of MRSA acquisition.

摘要

背景

紫外线（UV）消毒的临床效果尚不清楚。本研究旨在探讨在日本医院，在终末清洁方案中增加脉冲氙 UV（PX-UV）消毒对耐甲氧西林金黄色葡萄球菌（MRSA）获得率的影响。

方法

在重症和高护理病房治疗的患者出院或转科后，在手动终末清洁方案中增加使用 PX-UV 消毒设备。我们使用泊松回归模型，根据研究期间、PX-UV 干预状态、单位类型以及酒精基洗手液（ABHR）的消耗率，检查 MRSA 获得的发生率。

结果

干预单元中约 86%的房间使用 PX-UV 设备进行终末消毒。在干预单元中，MRSA 获得的发生率从非干预期的每 1000 个患者日 3.56 例降至干预期的每 1000 个患者日 2.21 例。此外，使用 PX-UV 消毒降低了 MRSA 获得的风险（发病率比：0.556；95%置信区间，0.309-0.999；P=0.0497）。ABHR 的消耗并未影响 MRSA 获得的风险。