Faculty of Pharmaceutical Sciences, University of Campinas (UNICAMP), Campinas, SP, Brazil.
Ophthalmology Department, Faculty of Medicine, University of São Paulo, São Paulo, Brazil.
Eur J Pharm Sci. 2021 Apr 1;159:105736. doi: 10.1016/j.ejps.2021.105736. Epub 2021 Jan 28.
Hydroxypropyl methylcellulose (HPMC) is a cellulose ether widely used in drug formulations due to its biocompatibility, uncharged nature, solubility in water and thermoplastic behavior. Particularly for ocular and ophthalmic formulations, HPMC is applied as viscosity enhancer agent in eye drops, gelling agent in injections, and polymeric matrix in films, filaments and inserts. The different therapeutic approaches are necessary due to the complex anatomic structure of the eye. The natural ocular barriers and the low drug permeation into the circulatory system make the drug administration challenging. This review presents the eye anatomy and the usual local routes of drugs administration, which are facilitated by the physicochemical properties of HPMC. The relationship between chemical structure and physicochemical properties of HPMC is displayed. The different types of formulations (local application) including HPMC for ocular drug delivery are discussed with basis on recent literature reports and patents.
羟丙基甲基纤维素（HPMC）是一种纤维素醚，由于其生物相容性、非荷电性、水溶性和热塑性，广泛应用于药物制剂中。特别是对于眼部和眼科制剂，HPMC 作为滴眼液中的增粘剂、注射剂中的凝胶剂以及薄膜、长丝和植入物中的聚合物基质被应用。由于眼睛的复杂解剖结构，需要不同的治疗方法。天然的眼部屏障和药物向循环系统的低渗透性使得药物给药具有挑战性。本综述介绍了眼睛解剖结构和常用的局部药物给药途径，这些途径得益于 HPMC 的物理化学性质。展示了 HPMC 的化学结构和物理化学性质之间的关系。根据最近的文献报道和专利，讨论了包括用于眼部药物递送的 HPMC 在内的不同类型的制剂（局部应用）。
