Hyman P E, Abrams C E, Dubois A
Department of Pediatrics, UCLA Harbor-UCLA Medical Center, Torrance 90502.
J Pediatr Gastroenterol Nutr. 1988 Mar-Apr;7(2):181-4.
In a double-blind, placebo-controlled, randomized study we measured the effect of 1 mg/kg intravenous metoclopramide on the gastric emptying of a 15 ml/kg 5% glucose meal, using a phenol red dye dilution technique. In a group of nine infants referred for multiple daily episodes of regurgitation, metoclopramide doubled the rate of gastric emptying (p less than 0.02). In six infants with prolonged gastroparesis following abdominal surgery, metoclopramide more than doubled the rate of gastric emptying (p less than 0.05). In contrast, in seven infants with gastroparesis related to prematurity, metoclopramide did not significantly change gastric emptying. No extrapyramidal side effects of metoclopramide occurred during the study.
在一项双盲、安慰剂对照、随机研究中，我们采用酚红染料稀释技术，测定了1毫克/千克静脉注射胃复安对15毫升/千克5%葡萄糖餐胃排空的影响。在一组因每日多次反流而转诊的9名婴儿中，胃复安使胃排空率提高了一倍（p<0.02）。在6名腹部手术后出现胃轻瘫延长的婴儿中，胃复安使胃排空率提高了一倍多（p<0.05）。相比之下，在7名与早产相关的胃轻瘫婴儿中，胃复安并未显著改变胃排空。研究期间未出现胃复安的锥体外系副作用。
