Monés J, Espinós J C, Carrió I, Calabuig R, Vilardell F
Med Clin (Barc). 1989 Sep 30;93(9):331-4.
The gastric emptying of solids was evaluated with radionuclide techniques in 16 patients with reflux esophagitis, demonstrated by two of the following methods: endoscopy, pathology, and/or pH measurement. The percentage of radionuclide remaining within the stomach was 80.8 +/- 17% after 45 minutes, 63.3 +/- 10% after 75 minutes, and 48.8 +/- 19% after 105 minutes, with a half time (T1/2) of gastric emptying of 103.4 +/- 6 minutes. These results showed significant differences in T1/2 with those from a control group of healthy individuals, the gastric emptying being slower in patients with esophagitis (103.4 min vs 85.3 min; p less than 0.01). Subsequently, a double blind study to assess the effect of metoclopramide and cinitapride on gastric emptying in patients with reflux esophagitis was carried out. Cinitapride accelerated the gastric emptying of solids with statistically significant differences when compared with placebo (84 min vs 104 min, p less than 0.05). In this study, metoclopramide showed a tendency to accelerate gastric emptying, although it did not achieve a significant difference with placebo.
采用放射性核素技术对16例反流性食管炎患者的固体食物胃排空情况进行了评估，通过以下两种或更多方法确诊：内镜检查、病理检查和/或pH测量。45分钟后胃内剩余放射性核素的百分比为80.8±17%，75分钟后为63.3±10%，105分钟后为48.8±19%，胃排空的半衰期（T1/2）为103.4±6分钟。这些结果显示，与健康个体对照组相比，T1/2存在显著差异，食管炎患者的胃排空较慢（103.4分钟对85.3分钟；p<0.01）。随后，开展了一项双盲研究，以评估甲氧氯普胺和西尼必利对反流性食管炎患者胃排空的影响。与安慰剂相比，西尼必利加速了固体食物的胃排空，差异具有统计学意义（84分钟对104分钟，p<0.05）。在本研究中，甲氧氯普胺虽有加速胃排空的趋势，但与安慰剂相比未达到显著差异。
