Novak M, Monkus E F, Buch M, Silverio J, Clouston O M, Cassady J C
Department of Pediatrics, University of Miami, School of Medicine, Florida 33101.
J Pediatr Gastroenterol Nutr. 1988 Mar-Apr;7(2):220-4. doi: 10.1097/00005176-198803000-00011.
The absence of carnitine in the diet of normal infants results in marked reduction of plasma carnitine levels. In order to evaluate the effects of L-carnitine supplementation of soybean formula, plasma and urine levels of free carnitine and acylcarnitine were compared in infants receiving carnitine-free soybean protein-based formula and the same formula supplemented with 50 and 250 nmol/ml L-carnitine. In infants receiving soybean formula with 50 nmol/ml L-carnitine, the plasma levels of free carnitine were not significantly different from those in infants receiving formula with 250 nmol/ml L-carnitine; however, urine levels of free carnitine were significantly increased when the infants received formula with 250 nmol/ml L-carnitine. In normal full-term infants, supplementation of soybean formula with 50 nmol/ml L-carnitine was sufficient to maintain normal plasma levels that were comparable to breast-fed infants.
正常婴儿饮食中缺乏肉碱会导致血浆肉碱水平显著降低。为了评估在大豆配方奶粉中添加左旋肉碱的效果，对食用不含肉碱的大豆蛋白配方奶粉以及添加了50和250 nmol/ml左旋肉碱的相同配方奶粉的婴儿的血浆和尿液中的游离肉碱及酰基肉碱水平进行了比较。在食用含50 nmol/ml左旋肉碱的大豆配方奶粉的婴儿中，游离肉碱的血浆水平与食用含250 nmol/ml左旋肉碱配方奶粉的婴儿相比无显著差异；然而，当婴儿食用含250 nmol/ml左旋肉碱的配方奶粉时，游离肉碱的尿液水平显著升高。在正常足月婴儿中，在大豆配方奶粉中添加50 nmol/ml左旋肉碱足以维持与母乳喂养婴儿相当的正常血浆水平。
