Structurally optimized suture resistant polylactic acid (PLA)/poly (є-caprolactone) (PCL) blend based engineered nanofibrous mats.

The structural fabrication and optimization of polylactic acid (PLA)/poly (є-caprolactone) (PCL) blend-based bead-free electrospun nanofibrous mats (ENMs) has been carried out by using Response Surface Methodology (RSM) and Taguchi design of experiments (DoE). From the three control parameters i.e., PCL content, N, N- dimethylformamide (DMF) content, and electrospinning solution concentration, the optimal parametric combinations for minimizing the bead defects amongst ENMs were obtained. The parametric optimization outcomes remained identical, from both RSM and Taguchi approaches, irrespective of the difference in the number of experimental trials. The experimental validation of the predicted results from Taguchi-design showed an excellent agreement with >95% accuracy concerning minimization of bead defects and average fiber diameter. The solution concentration was a key determinant in controlling the gross fiber morphology. The quasi-static mechanical response of the optimally designed ENMs showed a distinct role in structural aspects of fibers. The failure responses revealed the role of the structural network of ENMs in controlling the failure stress and network collapse that was also reiterated upon the outcomes of suture retention strength assessment. The optimally designed ENM structures showed a correspondingly optimal level of suture resistance, where fine fibers offered higher resistance to suture failure due to the cooperative network effects unlike the relatively coarse fiber-based ENMs undergoing collapse attributed to fiber buckling and fiber slippage in the labile structural network.