Department of Neurology, Al-Azhar University, Faculty of Medicine, Cairo, Egypt.
Internal Medicine Department, Al-Azhar University, Faculty of Medicine, Cairo, Egypt.
Complement Ther Clin Pract. 2021 May;43:101317. doi: 10.1016/j.ctcp.2021.101317. Epub 2021 Jan 23.
This randomized study aimed to evaluate the effect of green tea extract (GTE) intake on clinical and neurophysiological parameters in patients with mild-to-moderate diabetic peripheral neuropathy (DPN).
The present study included 194 patients with DPN. Patients were randomized into two treatment arms: GTE (n = 96) and placebo (n = 98) arms who received allocated treatment for 16 weeks. Symptoms of DPN were assessed using Toronto Clinical Scoring System (TCSS). Sensorineural pain was assessed using visual analog scale (VAS). Neural dysfunction was evaluated using the vibration perception thresholds (VPT). Assessments were made at baseline and after 4, 8, and 16 weeks of starting treatment.
At baseline and after 4 weeks of treatment, VAS, TCSS and VPT were comparable in the studied groups. However, after 8 weeks of treatment, patients in GTE group expressed lower VAS scores, significantly lower TCSS scores and significantly lower VPT. As treatment continued, the differences between groups regarding the outcome parameters became more evident at 16 weeks.
GTE intake may have a beneficial value in treatment of DPN.
本随机研究旨在评估绿茶提取物（GTE）摄入对轻中度糖尿病周围神经病变（DPN）患者的临床和神经生理参数的影响。
本研究纳入了 194 例 DPN 患者。患者被随机分为 GTE（n=96）和安慰剂（n=98）两组，两组患者均接受为期 16 周的分配治疗。采用多伦多临床评分系统（TCSS）评估 DPN 症状。采用视觉模拟评分法（VAS）评估感觉神经痛。采用振动感觉阈值（VPT）评估神经功能障碍。在基线和开始治疗后的 4、8 和 16 周进行评估。
在基线和治疗 4 周时，两组的 VAS、TCSS 和 VPT 均无差异。然而，在治疗 8 周后，GTE 组患者的 VAS 评分较低，TCSS 评分和 VPT 显著降低。随着治疗的继续，在 16 周时，两组之间在结局参数上的差异变得更加明显。
GTE 摄入对 DPN 的治疗可能具有有益的价值。
