伴有 1 个 IV 期因素的胃癌患者行转化手术后的预后因素。
Prognostic Factors for Gastric Cancer Patients With One Stage IV Factor who Underwent Conversion Surgery.
机构信息
Department of Gastrointestinal Surgery, Kanagawa Cancer Center, Yokohama, Japan.
Department of Gastrointestinal and Pediatric Surgery, Tokyo Medical University, Tokyo, Japan.
出版信息
Anticancer Res. 2021 Feb;41(2):1005-1012. doi: 10.21873/anticanres.14855.
BACKGROUND/AIM: To identify prognostic factors for patients with stage IV gastric cancer (GC) and a single stage IV factor before chemotherapy who underwent conversion surgery (R0 resection).
PATIENTS AND METHODS
This study retrospectively analysed 32 GC patients with a single stage IV factor before chemotherapy and who underwent conversion surgery (R0 resection) between January 2001 and September 2015. The univariate and multivariate analyses were performed to identify independent prognostic factors.
RESULTS
The five-year survival rate was 39.6%, and the median survival time was 47.0 months. In the univariate analysis, diffuse-type according to Lauren classification was significantly associated with worse overall survival (p<0.001). In the multivariate analysis, diffuse-type was selected as an independent prognostic factor (hazard ratio=15.970, 95% confidence interval=3.804-67.043, p<0.001).
CONCLUSION
Diffuse-type may be a useful prognostic factor in GC patients with a single stage IV factor who undergo conversion surgery (R0 resection).
背景/目的：确定接受转化手术（R0 切除）的 IV 期胃癌（GC）患者和化疗前单一 IV 期因素患者的预后因素。
患者和方法
本研究回顾性分析了 2001 年 1 月至 2015 年 9 月期间接受转化手术（R0 切除）的 32 例化疗前单一 IV 期因素的 GC 患者。进行了单因素和多因素分析，以确定独立的预后因素。
结果
五年生存率为 39.6%，中位生存时间为 47.0 个月。在单因素分析中，Lauren 分类的弥漫型与总生存明显相关（p<0.001）。在多因素分析中，弥漫型被选为独立的预后因素（风险比=15.970，95%置信区间=3.804-67.043，p<0.001）。
结论
弥漫型可能是接受转化手术（R0 切除）的单一 IV 期因素 GC 患者的有用预后因素。
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