胃癌手术治疗结局的临床病理预后因素。
Clinicopathological Prognostic Factors Determining Outcomes of Treatment in Gastric Cancer Surgery.
机构信息
Andrzej Frycz Modrzewski Medical Krakow University, Krakow, Poland;
First Department of General Surgery, Jagiellonian University, Collegium Medicum, Krakow, Poland.
出版信息
In Vivo. 2022 Nov-Dec;36(6):2927-2935. doi: 10.21873/invivo.13035.
BACKGROUND/AIM: The purpose of this study was to examine the impact of clinicopathological prognostic factors on tumor resectability, perioperative complications, and 5-year survival rates in patients with gastric cancer treated surgically.
PATIENTS AND METHODS
A cohort of 834 patients operated on for gastric cancer between 2007 and 2016 was analyzed.
RESULTS
Patients over 70 years of age manifested a significantly higher rate of overall complications, systemic complications, surgical complications, perioperative mortality, and a worse 5-year survival. The diffuse type according to the Lauren classification was an independent prognostic factor for perioperative mortality. TNM stage significantly influenced resectability and 5-year survival rates. Furthermore, the presence of distant metastases (M1 stage) significantly increased the rates of overall complications, systemic complications, and perioperative mortality.
CONCLUSION
Although TNM stage was the most important prognostic factor for resectability, perioperative complications and 5-year survival, other clinicopathological prognostic factors, such as age, and Lauren type also significantly affected treatment outcomes in gastric cancer surgery.
背景/目的：本研究旨在探讨临床病理预后因素对接受手术治疗的胃癌患者肿瘤可切除性、围手术期并发症和 5 年生存率的影响。
患者与方法
分析了 2007 年至 2016 年间接受胃癌手术的 834 例患者的队列。
结果
年龄超过 70 岁的患者总体并发症、全身并发症、手术并发症、围手术期死亡率更高，5 年生存率更差。Lauren 分类中的弥漫型是围手术期死亡率的独立预后因素。TNM 分期显著影响可切除性和 5 年生存率。此外，远处转移（M1 期）的存在显著增加了总体并发症、全身并发症和围手术期死亡率的发生率。
结论
尽管 TNM 分期是可切除性、围手术期并发症和 5 年生存率最重要的预后因素，但其他临床病理预后因素，如年龄和 Lauren 类型，也显著影响胃癌手术的治疗结果。
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