First Department of Surgery, Faculty of Medicine, University of Yamanashi, Yamanashi, Japan
First Department of Surgery, Faculty of Medicine, University of Yamanashi, Yamanashi, Japan.
Anticancer Res. 2021 Feb;41(2):1077-1082. doi: 10.21873/anticanres.14865.
BACKGROUND/AIM: This study examined the prognostic impact of the past history of breast cancer screening within the last 2 years (PH-BCS), for patients with triple negative breast cancer (TNBC), a subtype that carries extremely poor prognosis.
Eighty-six consecutive cases with TNBC, who underwent surgery at our faculty from 2009 to 2015, were divided into two groups according to PH-BCS. Prognostic analyses for disease-free survival and overall survival between the two groups were performed.
The positive PH-BCS group (n=44) had a significantly better prognoses than the negative PH-BCS group (n=42) (p<0.001). No recurrent cases were observed in the positive PH-BCS group. In the negative PH-BCS group, tumor and node status and chemotherapy were indicated as significant prognostic factors, and further step-wise multivariate analysis revealed only node status as a significant prognostic factor.
Breast cancer screening at least every 2 years may improve the prognosis of TNBC.
背景/目的：本研究旨在探讨过去 2 年内接受过乳腺癌筛查（PH-BCS）的三阴性乳腺癌（TNBC）患者的预后影响，TNBC 是一种预后极差的亚型。
86 例连续接受 TNBC 手术的患者，于 2009 年至 2015 年在我院接受治疗，根据 PH-BCS 将其分为两组。对两组的无病生存和总生存预后进行分析。
PH-BCS 阳性组（n=44）的预后明显优于 PH-BCS 阴性组（n=42）（p<0.001）。PH-BCS 阳性组无复发病例。在 PH-BCS 阴性组中，肿瘤和淋巴结状态以及化疗被认为是显著的预后因素，进一步的逐步多变量分析显示只有淋巴结状态是显著的预后因素。
至少每 2 年进行一次乳腺癌筛查可能会改善 TNBC 的预后。
