乳腺癌筛查史对三阴性乳腺癌预后的临床意义。
Clinical Significance of Past History of Breast Cancer Screening for the Prognosis of Triple Negative Breast Cancer.
机构信息
First Department of Surgery, Faculty of Medicine, University of Yamanashi, Yamanashi, Japan
First Department of Surgery, Faculty of Medicine, University of Yamanashi, Yamanashi, Japan.
出版信息
Anticancer Res. 2021 Feb;41(2):1077-1082. doi: 10.21873/anticanres.14865.
BACKGROUND/AIM: This study examined the prognostic impact of the past history of breast cancer screening within the last 2 years (PH-BCS), for patients with triple negative breast cancer (TNBC), a subtype that carries extremely poor prognosis.
PATIENTS AND METHODS
Eighty-six consecutive cases with TNBC, who underwent surgery at our faculty from 2009 to 2015, were divided into two groups according to PH-BCS. Prognostic analyses for disease-free survival and overall survival between the two groups were performed.
RESULTS
The positive PH-BCS group (n=44) had a significantly better prognoses than the negative PH-BCS group (n=42) (p<0.001). No recurrent cases were observed in the positive PH-BCS group. In the negative PH-BCS group, tumor and node status and chemotherapy were indicated as significant prognostic factors, and further step-wise multivariate analysis revealed only node status as a significant prognostic factor.
CONCLUSION
Breast cancer screening at least every 2 years may improve the prognosis of TNBC.
背景/目的：本研究旨在探讨过去 2 年内接受过乳腺癌筛查（PH-BCS）的三阴性乳腺癌（TNBC）患者的预后影响，TNBC 是一种预后极差的亚型。
患者与方法
86 例连续接受 TNBC 手术的患者，于 2009 年至 2015 年在我院接受治疗，根据 PH-BCS 将其分为两组。对两组的无病生存和总生存预后进行分析。
结果
PH-BCS 阳性组（n=44）的预后明显优于 PH-BCS 阴性组（n=42）（p<0.001）。PH-BCS 阳性组无复发病例。在 PH-BCS 阴性组中，肿瘤和淋巴结状态以及化疗被认为是显著的预后因素，进一步的逐步多变量分析显示只有淋巴结状态是显著的预后因素。
结论
至少每 2 年进行一次乳腺癌筛查可能会改善 TNBC 的预后。
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