Department of Hepatology, The First Hospital of Jilin University, Changchun, Jilin, China.
Department of Hepatopancreatobiliary Surgery, The First Hospital of Jilin University, Changchun, Jilin, China.
Technol Cancer Res Treat. 2021 Jan-Dec;20:1533033821990046. doi: 10.1177/1533033821990046.
Cancer is associated with genetic variants of DNA repair genes that alter DNA repair capacity. The aim of this meta-analysis was to evaluate the relations between the rs13181 and rs1799793 XPD gene polymorphisms and risk for hepatocellular carcinoma (HCC) and gastric cancer.
Relevant publications were systematically sought from Web of Science, Pubmed, and China Academic Journals Full-text Database. The selection of eligible studies was performed by 2 independent authors. A total of 32 case-control studies were included. Meta-analyses were undertaken in all study participants and each ethnic group.
The risk of HCC was significantly increased with the XPD rs13181 G allele (P = 0.028, pooled odds ratio (OR) = 1.36, 95% confidence interval (CI) = 1.03-1.80) in all study participants. A subgroup analysis by ethnicity showed that the association was significant in Chinese (P = 0.009, pooled OR = 1.49, 95% CI = 1.11-2.02), but not in Caucasians (P = 0.619, pooled OR = 1.17, 95% CI = 0.64-2.13). Meta-analysis of the XPD rs1799793 polymorphism and HCC showed an association between its variant T allele and increased HCC risk in all study participants (P = 0.017, pooled OR = 1.23, 95% CI = 1.04-1.46, all Chinese). Our results showed no associations between the XPD rs13181 G allele and rs1799793 T allele and gastric cancer risk (rs13181: P = 0.298, pooled OR = 1.10, 95% CI = 0.92-1.31; rs1799793: P = 0.068, pooled OR = 1.31, 95% CI = 0.98-1.74).
This meta-analysis demonstrated that the XPD rs13181 G allele and rs1799793 T allele have significant associations with HCC and may be risk factors for HCC in the Chinese population. Current evidence indicated that they are not related to gastric cancer risk.
癌症与改变 DNA 修复能力的 DNA 修复基因的遗传变异有关。本荟萃分析的目的是评估 XPD 基因 rs13181 和 rs1799793 多态性与肝细胞癌 (HCC) 和胃癌风险之间的关系。
系统地从 Web of Science、Pubmed 和中国学术期刊全文数据库中检索相关文献。由 2 名独立作者进行合格研究的选择。共有 32 项病例对照研究被纳入。对所有研究参与者和每个种族群体进行荟萃分析。
在所有研究参与者中，XPD rs13181 G 等位基因与 HCC 的风险显著增加（P = 0.028，合并优势比 (OR) = 1.36，95%置信区间 (CI) = 1.03-1.80）。按种族亚组分析显示，在中国人群中该关联具有显著性（P = 0.009，合并 OR = 1.49，95%CI = 1.11-2.02），但在高加索人群中无显著性（P = 0.619，合并 OR = 1.17，95%CI = 0.64-2.13）。XPD rs1799793 多态性与 HCC 的荟萃分析显示，其变异 T 等位基因与所有研究参与者 HCC 风险增加之间存在关联（P = 0.017，合并 OR = 1.23，95%CI = 1.04-1.46，所有中国人）。我们的结果显示 XPD rs13181 G 等位基因和 rs1799793 T 等位基因与胃癌风险之间无关联（rs13181：P = 0.298，合并 OR = 1.10，95%CI = 0.92-1.31；rs1799793：P = 0.068，合并 OR = 1.31，95%CI = 0.98-1.74）。
本荟萃分析表明，XPD rs13181 G 等位基因和 rs1799793 T 等位基因与 HCC 具有显著相关性，可能是中国人 HCC 的危险因素。目前的证据表明，它们与胃癌风险无关。
