Division of Neonatology, Department of Pediatrics, University of Illinois at Chicago, 840 South Wood Street, MC 856, Suite 1252, Chicago, IL 60612, USA.
Division of Gastroenterology and Hepatology, Department of Medicine, University of Illinois at Chicago, 840 South Wood Street, Room 704 CSB, MC716, Chicago, IL 60612, USA.
Gastroenterol Clin North Am. 2021 Mar;50(1):77-100. doi: 10.1016/j.gtc.2020.10.008. Epub 2021 Jan 5.
Bacterial colonization of the intestines occurs during the first 2 years of life. Homeostasis of the gut microbiome is established to foster normal intestinal immune development for adulthood. Derangements in this process can interfere with immune function and increase an individual's risk for gastrointestinal disorders. We discuss the role of diet and the microbiome on the onset of such disorders. We examine how micronutrients, prebiotics, and probiotics modulate disease pathogenesis. We discuss how diet and abnormal microbial colonization impact extraintestinal organs. Understanding the communication of nutrition and the microbiome offers exciting opportunities for therapeutics.
肠道细菌定植发生于生命的头 2 年。肠道微生物组的稳态建立有助于促进成年期正常肠道免疫发育。该过程的紊乱会干扰免疫功能，增加个体发生胃肠道疾病的风险。我们讨论了饮食和微生物组在这些疾病发病中的作用。我们研究了微量营养素、益生元和益生菌如何调节疾病发病机制。我们讨论了饮食和异常微生物定植如何影响肠外器官。了解营养与微生物组的交流为治疗提供了令人兴奋的机会。
