Cooney Laura G, Dokras Anuja
Department of Obstetrics and Gynecology, University of Wisconsin, Generations Fertility Care, 2365 Deming Way, Middleton, WI 53562, USA.
Department of Obstetrics and Gynecology, University of Pennsylvania, Penn Fertility Care, 3701 Market Street, Suite 800, Philadelphia, PA 19085, USA.
Endocrinol Metab Clin North Am. 2021 Mar;50(1):83-95. doi: 10.1016/j.ecl.2020.11.001. Epub 2021 Jan 9.
Polycystic ovary syndrome is a common endocrine disorder in reproductive-aged women and is associated with an increased risk of metabolic abnormalities, including obesity, impaired glucose tolerance, diabetes, dyslipidemia, metabolic syndrome, venous thromboembolism, and subclinical atherosclerosis. Clinicians and patients alike need to be aware of these increased risks as well as new international guidelines that recommend frequent screening and active management of metabolic abnormalities. Given that the data on risk of cardiovascular events, such as myocardial infarction and stroke, in women with PCOS is mixed, future large-scale, longitudinal studies are needed to clarify these potential risks.
多囊卵巢综合征是育龄女性常见的内分泌紊乱疾病，与代谢异常风险增加相关，包括肥胖、糖耐量受损、糖尿病、血脂异常、代谢综合征、静脉血栓栓塞和亚临床动脉粥样硬化。临床医生和患者都需要了解这些增加的风险以及推荐对代谢异常进行频繁筛查和积极管理的新国际指南。鉴于多囊卵巢综合征女性发生心血管事件（如心肌梗死和中风）的风险数据不一，未来需要进行大规模纵向研究以明确这些潜在风险。
