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在 2019 冠状病毒病早期阶段进行肾移植:使用逆转录聚合酶链反应和低辐射剂量胸部计算机断层扫描筛选患者。

Navigating Kidney Transplantation in the Early Phase of Coronavirus Disease 2019: Screening Patients With Reverse Transcriptase Polymerase Chain Reaction and Low-Radiation-Dose Chest Computed Tomography.

机构信息

Department of Surgery, Division of Transplantation, Penn State Health Milton S. Hershey Medical Center, Hershey, Pennsylvania.

Department of Medicine, Division of Infectious Diseases, Penn State Health Milton S. Hershey Medical Center, Hershey, Pennsylvania.

出版信息

Transplant Proc. 2021 May;53(4):1169-1174. doi: 10.1016/j.transproceed.2021.01.001. Epub 2021 Jan 9.

DOI:10.1016/j.transproceed.2021.01.001
PMID:33518290
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7796654/
Abstract

BACKGROUND

The coronavirus disease 2019 (COVID-19) pandemic of 2020 changed organ transplantation. All elective cases at our institution were postponed for approximately 3 months. Centers for Medicare and Medicaid Services considers organ transplant surgery a Tier 3b case, along with other high acuity procedures, recommending no postponement. Our transplant program collaborated with our transplant infectious disease colleagues to create a protocol that would ensure both patient and staff safety during these unprecedented times.

METHODS

The living donor program was electively placed on hold until we had the proper protocols in place. Preoperative COVID-19 testing was required for all recipients and living donors. All patients underwent a rapid nasopharyngeal swab test. After testing negative by nasopharyngeal swab, recipients also underwent a low-radiation-dose computed tomography scan to rule out any radiographic changes suggestive of a COVID-19 infection.

RESULTS

We performed 8 living donor and 9 deceased donor kidney transplants. In comparison, we performed 10 living donor and 4 deceased donor transplants during the same time period in the previous year. Our testing protocol enabled efficient use of all suitable organs offered during the viral pandemic. No recipients or living donors tested positive or developed COVID-19.

CONCLUSIONS

Creation of a viral testing protocol, developed in conjunction with our infectious disease team, permitted kidney transplantation to be performed safely, and the number of deceased donor transplants increased considerably without adversely affecting our outcomes.

摘要

背景

2020 年的新冠肺炎疫情改变了器官移植。我们机构的所有择期病例都被推迟了大约 3 个月。医疗保险和医疗补助服务中心(Centers for Medicare and Medicaid Services)认为器官移植手术属于第 3b 类病例,与其他高急症手术一起,建议不要推迟。我们的移植项目与移植传染病学同事合作,制定了一项协议,以确保在这些前所未有的时期患者和工作人员的安全。

方法

活体供者计划被暂时搁置,直到我们制定了适当的方案。所有受者和活体供者都需要进行 COVID-19 术前检测。所有患者均进行了快速鼻咽拭子检测。鼻咽拭子检测阴性后,受者还进行了低辐射剂量 CT 扫描,以排除任何提示 COVID-19 感染的放射学改变。

结果

我们进行了 8 例活体供者和 9 例已故供者的肾脏移植。相比之下,在去年同期,我们进行了 10 例活体供者和 4 例已故供者的移植。我们的检测方案使在病毒大流行期间提供的所有合适器官都得到了有效利用。没有受者或活体供者检测呈阳性或感染 COVID-19。

结论

与传染病学团队合作制定的病毒检测方案,使肾脏移植能够安全进行,而且在不影响我们结果的情况下,已故供者的移植数量大大增加。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9b95/7796654/7880d9c6511e/gr2_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9b95/7796654/5b9c060c1bd9/gr1_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9b95/7796654/7880d9c6511e/gr2_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9b95/7796654/5b9c060c1bd9/gr1_lrg.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9b95/7796654/7880d9c6511e/gr2_lrg.jpg

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Transplant Proc. 2021 May;53(4):1169-1174. doi: 10.1016/j.transproceed.2021.01.001. Epub 2021 Jan 9.
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