HIV Dynamics and Replication Program, Center for Cancer Research, National Cancer Institute, Frederick, MD, USA.
HIV Dynamics and Replication Program, Center for Cancer Research, National Cancer Institute, Frederick, MD, USA.
Trends Genet. 2021 May;37(5):406-410. doi: 10.1016/j.tig.2021.01.004. Epub 2021 Jan 29.
The CD225 superfamily regulates vesicular membrane fusion events essential to neurotransmission, immunity, development, and metabolism. Its importance to physiology is reinforced by the identification of polymorphisms associated with disease. This article highlights the shared features that drive the function of CD225 proteins such as interferon-inducible transmembrane proteins 3 (IFITM3) and proline-rich transmembrane protein 2 (PRRT2) and is intended to catalyze efforts towards characterizing the lesser-known family members.
CD225 超家族调节囊泡膜融合事件，这些事件对神经传递、免疫、发育和代谢至关重要。与疾病相关的多态性的鉴定增强了其对生理学的重要性。本文强调了驱动 CD225 蛋白（如干扰素诱导跨膜蛋白 3 (IFITM3) 和富含脯氨酸的跨膜蛋白 2 (PRRT2)）功能的共同特征，旨在促进对鲜为人知的家族成员进行特征描述。
