Medical Psychology, Radboud Institute for Health Sciences, Radboud university medical center, Nijmegen, The Netherlands
Medical Psychology, Radboud Institute for Health Sciences, Radboud university medical center, Nijmegen, The Netherlands.
BMJ Open. 2021 Jan 31;11(1):e042404. doi: 10.1136/bmjopen-2020-042404.
A better understanding of the molecular, genetic and immunological characteristics of cancer and the introduction of new systemic treatment regimens in the last decades, has led to better treatment outcomes and increased survival rates for patients with previously short lived cancers. However, there is no uniform description to refer to this growing group of patients with advanced cancer who now respond to new systemic treatments for longer periods. Furthermore, little is known about the unique psychological challenges these patients face, living with ongoing uncertainty about the course of their disease and life expectancy. The objective of this scoping review is to identify the psychological aspects experienced by, and the definitions used to refer to patients with advanced cancer receiving lifelong systemic treatment.
This review will be among the first to summarise literature on the psychological issues in the growing group of advanced cancer patients undergoing long-term systemic treatment. Articles will be retrieved from six databases (MEDLINE, Embase, Web of Science, PsycINFO, CINAHL and the Cochrane Database of Systematic Reviews) and reviewed for eligibility by two investigators independently. Definitions and psychological challenges will be extracted and narratively summarised following a descriptive approach. Furthermore, results will contribute in providing a uniform definition for this patient group, and help to identify knowledge gaps to give direction to further research in this field.
No ethical approval is required. The results of the scoping review will be submitted for publication to a scientific journal and presented at relevant conferences.
在过去几十年中，对癌症的分子、遗传和免疫学特征的更好理解，以及新的全身性治疗方案的引入，导致了患者治疗效果的改善和生存率的提高，这些患者以前的存活时间都较短。然而，对于这组越来越多的晚期癌症患者，他们现在对新的全身性治疗有更长时间的反应，目前还没有一个统一的描述来指代他们。此外，对于这些患者所面临的独特的心理挑战，人们知之甚少，他们对疾病进程和预期寿命的持续不确定性感到不安。本综述的目的是确定正在接受终身系统治疗的晚期癌症患者所经历的心理方面，并确定用于指代这些患者的定义。
这将是首次总结关于接受长期系统治疗的晚期癌症患者群体中出现的心理问题的文献综述。文章将从六个数据库（MEDLINE、Embase、Web of Science、PsycINFO、CINAHL 和 Cochrane 系统评价数据库）中检索，并由两名调查员独立进行资格审查。将提取并按照描述性方法进行叙述性总结定义和心理挑战。此外，研究结果将有助于为这一患者群体提供一个统一的定义，并有助于确定该领域进一步研究的知识空白。
不需要伦理批准。该综述的结果将提交给科学期刊发表，并在相关会议上展示。
