Clinical Sciences, Murdoch Children's Research Institute, Parkville, Victoria, Australia
Newborn Research, Royal Women's Hospital, Parkville, Victoria, Australia.
BMJ Open. 2021 Jan 31;11(1):e044491. doi: 10.1136/bmjopen-2020-044491.
Children born moderate to late preterm (MLP, 32-36 weeks' gestation) account for approximately 85% of all preterm births globally. Compared with children born at term, children born MLP are at increased risk of poor neurodevelopmental outcomes. Despite making up the largest group of preterm children, developmental outcomes of children born MLP are less well studied than in other preterm groups. This study aimed to (1) compare neurodevelopmental, respiratory health and brain magnetic resonance imaging (MRI) outcomes between children born MLP and term at 9 years of age; (2) examine the differences in brain growth trajectory from infancy to 9 years between children born MLP and term; and in children born MLP; (3) examine the relationship between brain development and neurodevelopment at 9 years; and (4) identify risk factors for poorer outcomes at 9 years.
The "LaPrem" (te term RI Study) study is a longitudinal cohort study of children born MLP and term controls, born at the Royal Women's Hospital in Melbourne, Australia, between 2010 and 2013. Participants were recruited in the neonatal period and were previously followed up at 2 and 5 years. This 9-year school-age follow-up includes neuropsychology, motor and physical activities, and lung function assessments, as well as brain MRI. Outcomes at 9 years will be compared between birth groups using linear and logistic regressions. Trajectories of brain development will be compared between birth groups using mixed effects models. The relationships between MRI and neurodevelopmental outcomes, as well as other early predictors of poor 9-year outcomes, will be explored using linear and logistic regression.
This study was approved by the human research ethics committee at the Royal Children's Hospital, Melbourne, Australia. Study outcomes will be disseminated through peer-reviewed publications, conference presentations and social media.
全球约有 85%的早产儿属于中度至晚期早产儿（MLP，32-36 周妊娠）。与足月出生的儿童相比，MLP 出生的儿童神经发育不良结局的风险增加。尽管 MLP 出生的早产儿占最大比例，但与其他早产儿群体相比，MLP 出生的早产儿的发育结果研究较少。本研究旨在：（1）比较 9 岁时 MLP 出生和足月出生儿童的神经发育、呼吸健康和脑磁共振成像（MRI）结果；（2）研究 MLP 出生和足月出生儿童从婴儿期到 9 岁的大脑生长轨迹差异；（3）研究脑发育与 9 岁时神经发育的关系；（4）确定 9 岁时较差结局的危险因素。
“LaPrem”（婴儿期研究）研究是一项在澳大利亚墨尔本皇家妇女医院出生于 2010 年至 2013 年间的 MLP 出生和足月对照儿童的纵向队列研究。参与者在新生儿期招募，并在 2 岁和 5 岁时进行了之前的随访。本次 9 岁学龄期随访包括神经心理学、运动和身体活动以及肺功能评估，以及脑 MRI。使用线性和逻辑回归比较出生组之间的 9 岁时结局。使用混合效应模型比较出生组之间的脑发育轨迹。使用线性和逻辑回归探索 MRI 与神经发育结果以及其他 9 岁时不良结局的早期预测因素之间的关系。
本研究得到了澳大利亚墨尔本皇家儿童医院的人类研究伦理委员会的批准。研究结果将通过同行评议的出版物、会议演讲和社交媒体进行传播。
