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弥漫性肺泡出血与扩张型心肌病和睡眠呼吸暂停综合征相关。

Diffuse Alveolar Hemorrhage Associated with Dilated Cardiomyopathy and Sleep Apnea Syndrome.

机构信息

Division of Infectious Diseases and Respiratory Medicine, Department of Internal Medicine, National Defense Medical College, Japan.

Department of Radiology, National Defense Medical College, Japan.

出版信息

Intern Med. 2021 Jun 15;60(12):1911-1914. doi: 10.2169/internalmedicine.5219-20. Epub 2021 Feb 1.

DOI:10.2169/internalmedicine.5219-20
PMID:33518557
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8263192/
Abstract

We herein report a case of diffuse alveolar hemorrhage (DAH) associated with dilated cardiomyopathy (DCM) and sleep apnea syndrome (SAS) in a 47-year-old man. The patient exhibited recurring dyspnea and bloody sputum. Chest radiography showed bilateral diffuse infiltrative opacities without pleural effusion. A bronchoscopic analysis of bronchoalveolar lavage fluid revealed hemosiderin-laden macrophages. Based on these findings, he was diagnosed with DAH. Laboratory and pathological findings ruled out the possibility of collagen diseases and vasculitis. Overnight polysomnography revealed concomitant severe obstructive SAS. Treatment with continuous positive-pressure ventilation and pharmacological therapy for DCM prevented recurrence of DAH.

摘要

我们在此报告一例与扩张型心肌病(DCM)和睡眠呼吸暂停综合征(SAS)相关的弥漫性肺泡出血(DAH)病例。该患者表现为反复呼吸困难和咯血。胸部 X 线显示双侧弥漫性渗出性混浊,无胸腔积液。支气管肺泡灌洗液的支气管镜分析显示含铁血黄素吞噬细胞。基于这些发现,他被诊断为 DAH。实验室和病理检查排除了胶原病和血管炎的可能性。整夜多导睡眠图显示同时存在严重的阻塞性 SAS。持续气道正压通气和 DCM 的药物治疗预防了 DAH 的复发。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/81f1/8263192/432db6c56589/1349-7235-60-1911-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/81f1/8263192/f1cc84adbcb9/1349-7235-60-1911-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/81f1/8263192/de629c5e7abe/1349-7235-60-1911-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/81f1/8263192/2eee7589185d/1349-7235-60-1911-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/81f1/8263192/432db6c56589/1349-7235-60-1911-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/81f1/8263192/f1cc84adbcb9/1349-7235-60-1911-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/81f1/8263192/de629c5e7abe/1349-7235-60-1911-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/81f1/8263192/2eee7589185d/1349-7235-60-1911-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/81f1/8263192/432db6c56589/1349-7235-60-1911-g004.jpg

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本文引用的文献

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Diffuse Alveolar Hemorrhaging with Hypertensive Emergency: A Rare but Important Cause of Hemoptysis.伴有高血压急症的弥漫性肺泡出血:咯血的一种罕见但重要的病因。
Intern Med. 2019 May 15;58(10):1511-1516. doi: 10.2169/internalmedicine.0920-18. Epub 2019 Feb 1.
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Diffuse alveolar haemorrhage with predominant upper lung lobe involvement associated with congestive heart failure: a case series.以肺上叶为主的弥漫性肺泡出血伴充血性心力衰竭:病例系列
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Clinical Features of Patients with Diffuse Alveolar Hemorrhage due to Negative-Pressure Pulmonary Edema.
负压性肺水肿致弥漫性肺泡出血患者的临床特征。
Lung. 2017 Aug;195(4):477-487. doi: 10.1007/s00408-017-0011-8. Epub 2017 Apr 28.
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Diffuse Alveolar Hemorrhage in Autoimmune Diseases.自身免疫性疾病中的弥漫性肺泡出血
Curr Rheumatol Rep. 2017 May;19(5):27. doi: 10.1007/s11926-017-0651-y.
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Intern Med. 2015;54(3):319-24. doi: 10.2169/internalmedicine.54.3057.
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