阿佩尔综合征的智力发育：29例患者的长期随访
Intellectual development in Apert's syndrome: a long term follow up of 29 patients.
作者信息
Patton M A, Goodship J, Hayward R, Lansdown R
机构信息
Hospitals for Sick Children, London.
出版信息
J Med Genet. 1988 Mar;25(3):164-7. doi: 10.1136/jmg.25.3.164.
Abstract
Twenty-nine patients with Apert's syndrome were ascertained through hospital records. The mean age was 19.3 years (range eight to 35 years). Further information was obtained on their intelligence, education, and employment records. Fourteen patients (48%) had a normal or borderline IQ (greater than 70), nine patients (31%) were mildly mentally retarded (IQ 50 to 70), four patients (14%) were moderately retarded (IQ 35 to 49), and two patients (7%) were severely retarded (IQ less than 35). Early craniectomy did not appear to improve intellectual outcome. Six of the seven school leavers with normal or borderline intelligence were in full time employment or vocational training.
摘要
通过医院记录确定了29例患有阿佩尔综合征的患者。平均年龄为19.3岁（范围为8至35岁）。还获取了他们的智力、教育和就业记录方面的进一步信息。14名患者（48%）智商正常或处于临界值（大于70），9名患者（31%）轻度智力发育迟缓（智商50至70），4名患者（14%）中度智力发育迟缓（智商35至49），2名患者（7%）重度智力发育迟缓（智商低于35）。早期颅骨切除术似乎并未改善智力结果。7名智商正常或处于临界值的离校学生中有6人在全职工作或接受职业培训。
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