Lv Zhi, Chen Qingqing, Jiang Yinling, Hu Panpan, Zhang Lei, Bai Tongjian, Wang Kai, Wang Yongsheng, Fan Xiaoyun
Department of Geriatric Respiratory and Critical Care Medicine, The First Affiliated Hospital of Anhui Medical University, Hefei, China.
Department of Pulmonary, The Second People's Hospital of Hefei (The Affiliated Hefei Hospital of Anhui Medical University), Hefei, China.
Front Hum Neurosci. 2021 Jan 15;14:580238. doi: 10.3389/fnhum.2020.580238. eCollection 2020.
Patients with chronic obstructive pulmonary disease (COPD) are characterized by attenuated pulmonary function and are frequently reported with cognitive impairments, especially memory impairments. The mechanism underlying the memory impairments still remains unclear. We applied resting-state functional magnetic resonance imaging (RS-fMRI) to compare the brain local activities with static and dynamic amplitude of low-frequency fluctuations (sALFF, dALFF) among patients with COPD ( = 32) and healthy controls (HC, = 30). Compared with HC, COPD patients exhibited decreased sALFF in the right basal ganglia and increased dALFF in the bilateral parahippocampal/hippocampal gyrus. The reduced the left basal ganglia was associated with lower oxygen partial pressure. Besides, the increased dALFF in the left hippocampal/parahippocampal cortex was associated with poor semantic-memory performance and the increased dALFF in the left hippocampal/parahippocampal cortex was associated the forced vital capacity. The present study revealed the abnormal static and dynamic local-neural activities in the basal ganglia and parahippocampal/hippocampal cortex in COPD patient and its relationship with poor lung function and semantic-memory impairments.
慢性阻塞性肺疾病（COPD）患者的特征是肺功能减弱，且经常被报道存在认知障碍，尤其是记忆障碍。记忆障碍背后的机制仍不清楚。我们应用静息态功能磁共振成像（RS-fMRI）比较了32例COPD患者和30例健康对照（HC）大脑局部活动与低频波动的静态和动态幅度（sALFF、dALFF）。与HC相比，COPD患者右侧基底节区的sALFF降低，双侧海马旁回/海马回的dALFF增加。左侧基底节区的降低与较低的氧分压有关。此外，左侧海马/海马旁回皮质dALFF增加与语义记忆表现差有关，左侧海马/海马旁回皮质dALFF增加与用力肺活量有关。本研究揭示了COPD患者基底节区和海马旁回/海马回皮质静态和动态局部神经活动异常及其与肺功能差和语义记忆障碍的关系。
