Wang Zhiyan, Cai Xiaodong, Qiu Rirang, Yao Chen, Tian Ye, Gong Chen, Zhang Yingli, Xu Bin, Zhang Doudou, Zang Yu, Liu Jiali, Peng Bo, Li Luming
National Engineering Laboratory for Neuromodulation, Tsinghua University School of Aerospace Engineering, Tsinghua University, Beijing, China.
Department of Neurosurgery, Shenzhen Second People's Hospital, the First Affiliated Hospital of Shenzhen University, Shenzhen, China.
Front Psychiatry. 2021 Jan 13;11:616501. doi: 10.3389/fpsyt.2020.616501. eCollection 2020.
Treatment-resistant depression (TRD) is a chronic and severe psychiatric illness associated with limited therapeutic options. Deep brain stimulation (DBS) is a promising therapy for TRD patients. However, its safety and efficacy are still unclear. Here we reported the safety and efficacy of lateral habenula (LHb) DBS for a TRD patient who had failed medical, psychological, electroconvulsive, and ketamine therapy. The DBS system is compatible with 3T magnetic resonance imaging along with local field potential (LFP) streaming. Two DBS electrodes were implanted at the bilateral LHb without any complication. The patient showed acute stimulation effects and achieved long-term improvements in his depression, anxiety, and sleep with left LHb 160 Hz frequency stimulation, accompanying the change of LFPs. These results provided clinical evidence toward the safety and efficacy and electrophysiological basis of LHb DBS for TRD.
难治性抑郁症（TRD）是一种慢性重症精神疾病，治疗选择有限。深部脑刺激（DBS）是一种有望用于TRD患者的治疗方法。然而，其安全性和有效性仍不明确。在此，我们报告了外侧缰核（LHb）DBS对一名药物、心理、电休克及氯胺酮治疗均无效的TRD患者的安全性和有效性。该DBS系统与3T磁共振成像以及局部场电位（LFP）流兼容。两个DBS电极植入双侧LHb，未出现任何并发症。患者在左侧LHb 160 Hz频率刺激下表现出急性刺激效果，并在抑郁、焦虑和睡眠方面实现了长期改善，同时伴有LFP的变化。这些结果为LHb DBS治疗TRD的安全性、有效性及电生理基础提供了临床证据。
