Walton Lois, Domellöf Magdalena Eriksson, Boraxbekk Carl-Johan, Domellöf Erik, Rönnqvist Louise, Bäckström David, Forsgren Lars, Stigsdotter Neely Anna
Department of Social and Psychological Studies, Karlstad University, Karlstad, Sweden.
Department of Psychology, Umeå University, Umeå, Sweden.
Front Psychol. 2021 Jan 13;11:587925. doi: 10.3389/fpsyg.2020.587925. eCollection 2020.
In Parkinson's disease (PD), the fronto-striatal network is involved in motor and cognitive symptoms. Working memory (WM) updating training engages this network in healthy populations, as observed by improved cognitive performance and increased striatal BOLD signal. This two-part study aimed to assess the feasibility of WM updating training in PD and measure change in cognition, movement and functional brain response in one individual with PD after WM updating training. A feasibility and single-subject (FL) study were performed in which patients with PD completed computerized WM updating training. The outcome measures were the pre-post changes in criterion and transfer cognitive tests; cognitive complaints; psychological health; movement kinematics; and task-related BOLD signal. Participants in the feasibility study showed improvements on the criterion tests at post-test. FL displayed the largest improvements on the criterion tests and smaller improvements on transfer tests. Furthermore, FL reported improved cognitive performance in everyday life. A shorter onset latency and smoother upper-limb goal-directed movements were measured at post-test, as well as increased activation within the striatum and decreased activation throughout the fronto-parietal WM network. This two-part study demonstrated that WM updating training is feasible to complete for PD patients and that change occurred in FL at post-test in the domains of cognition, movement and functional brain response.
在帕金森病（PD）中，额-纹状体网络与运动和认知症状有关。工作记忆（WM）更新训练在健康人群中会激活该网络，这可通过认知表现的改善和纹状体BOLD信号的增加观察到。这项分为两部分的研究旨在评估WM更新训练在PD患者中的可行性，并测量一名PD患者在接受WM更新训练后认知、运动和功能性脑反应的变化。进行了一项可行性和单受试者（FL）研究，其中PD患者完成了计算机化的WM更新训练。结果测量指标包括标准和迁移认知测试的前后变化；认知主诉；心理健康；运动运动学；以及与任务相关的BOLD信号。可行性研究中的参与者在测试后标准测试中有改善。FL在标准测试中显示出最大的改善，在迁移测试中的改善较小。此外，FL报告在日常生活中的认知表现有所改善。测试后测量到起始潜伏期缩短和上肢目标导向运动更平滑，以及纹状体内激活增加和额顶叶WM网络整体激活减少。这项分为两部分的研究表明，WM更新训练对PD患者来说是可行的，并且在测试后FL在认知、运动和功能性脑反应方面发生了变化。
